Evidence map›Paper›PMID 26595729›Full record

ReviewAnnals of the American Thoracic Society2015

Virus/Allergen Interaction in Asthma Exacerbation.

James E Gern

Open access · greenAbstract readReview
In one paragraph

Review in Annals of the American Thoracic Society, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 42 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Allergen-induced DNA release by the airway epithelium amplifies type 2 immunity.The Journal of allergy and clinical immunology · 2023
    Article
  8. Review
  9. Article
  10. Exacerbation-Prone Asthma.The journal of allergy and clinical immunology. In practice · 2020
    Article
  11. Article
  12. Article
  13. Review
  14. Effects of Omalizumab on Rhinovirus Infections, Illnesses, and Exacerbations of Asthma.American journal of respiratory and critical care medicine · 2017
    Article
  15. Airway and serum biochemical correlates of refractory neutrophilic asthma.The Journal of allergy and clinical immunology · 2017
    Article
  16. Reply.The Journal of allergy and clinical immunology · 2017
    Article
  17. Review
  18. From IgE to Omalizumab.Journal of immunology (Baltimore, Md. : 1950) · 2016
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

James E GernDepartment of Pediatrics and Department of Medicine, University of Wisconsin-Madison, Madison, Wisconsin.
University of Wisconsin–Madison · US

Funding

Inner City Asthma consortium 3 (ICAC3)UM1AI114271 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI GERN, JAMES E., JACKSON, DANIEL J · 2014 to 2021
$79.4M
Virus-Bacterial Interactions and Exacerba of AsthmaP01HL070831 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI GERN, JAMES E. · 2002 to 2017
$31.3M
Wisconsin Infant Study Cohort (WISC)U19AI104317 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI Irene M Ong · 2013 to 2026
$22.5M
NHLBI NIH HHS P01 HL070831NIAID NIH HHS U19 AI104317NIAID NIH HHS UM1 AI114271
6 · The paper itself

Abstract

Allergy and viral respiratory infections have long been recognized as two of the most important risk factors for exacerbations of asthma. These observations have raised questions regarding potential interactions between these two important risk factors. For example, does allergy diminish the antiviral response, thereby promoting exacerbations of asthma? Alternately, do viral respiratory infections potentiate ongoing allergic inflammation in the airway? The answers to these questions are likely to have implications regarding the prevention and treatment of exacerbations of asthma. This article reviews that clinical evidence linking viral infections and allergy to exacerbations of asthma, reviews potential interactions between these two risk factors, and discusses possible application of new insights in virus/allergen interactions to the prevention and treatment of exacerbations of asthma.

Indexed as

RhinovirusAllergensAsthmaCytokinesDisease ProgressionHealth Care CostsHumansHypersensitivityInflammationPicornaviridae InfectionsRandomized Controlled Trials as TopicRisk FactorsAllergensCytokinesallergyasthmainterferonrhinovirus

Identifiers

PMID26595729
PMCPMC4722838
OpenAlexW2174299018

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.