ArticleJournal of proteome research2015
Mass Spectrometry and Antibody-Based Characterization of Blood Vessels from Brachylophosaurus canadensis.
Article in Journal of proteome research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 74 citations in OpenAlex.
- In situ analysis of vascular structures in fractured Tyrannosaurus rex rib.Scientific reports · 2025Article
- Taphonomic variation in vascular remains from Mesozoic non-avian dinosaurs.Scientific reports · 2025Article
- Age is just a number: Examining the preservation of cells and soft tissues in Bothriolepis and other Devonian fish.PloS one · 2025Article
- Biomolecules in Pleistocene fossils from tropical cave indicate fossil biofilm.Scientific reports · 2024Article
- Paleontology in the 21st Century.Biology · 2023Article
- Biomolecular histology as a novel proxy for ancient DNA and protein sequence preservation.Ecology and evolution · 2022Article
- Paleoproteomics.Chemical reviews · 2022Review
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- Molecular tests support the viability of rare earth elements as proxies for fossil biomolecule preservation.Scientific reports · 2020Article
- Confirmation of ovarian follicles in an enantiornithine (Aves) from the Jehol biota using soft tissue analyses.Communications biology · 2020Article
- Evidence of proteins, chromosomes and chemical markers of DNA in exceptionally preserved dinosaur cartilage.National science review · 2020Article
- Genome-centric resolution of novel microbial lineages in an excavated Centrosaurus dinosaur fossil bone from the Late Cretaceous of North America.Environmental microbiome · 2020Article
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- Mechanisms of soft tissue and protein preservation in Tyrannosaurus rex.Scientific reports · 2019Article
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- Ancient amino acids from fossil feathers in amber.Scientific reports · 2019Article
- Elucidation of cross-species proteomic effects in human and hominin bone proteome identification through a bioinformatics experiment.BMC evolutionary biology · 2018Article
Corrections and comments
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Authors and funding
14 authors at 6 institutions in 2 countries.
Funding
Abstract
Structures similar to blood vessels in location, morphology, flexibility, and transparency have been recovered after demineralization of multiple dinosaur cortical bone fragments from multiple specimens, some of which are as old as 80 Ma. These structures were hypothesized to be either endogenous to the bone (i.e., of vascular origin) or the result of biofilm colonizing the empty osteonal network after degradation of original organic components. Here, we test the hypothesis that these structures are endogenous and thus retain proteins in common with extant archosaur blood vessels that can be detected with high-resolution mass spectrometry and confirmed by immunofluorescence. Two lines of evidence support this hypothesis. First, peptide sequencing of Brachylophosaurus canadensis blood vessel extracts is consistent with peptides comprising extant archosaurian blood vessels and is not consistent with a bacterial, cellular slime mold, or fungal origin. Second, proteins identified by mass spectrometry can be localized to the tissues using antibodies specific to these proteins, validating their identity. Data are available via ProteomeXchange with identifier PXD001738.
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