Evidence map›Paper›PMID 26595481›Full record

ArticleJournal of abnormal psychology2015

A multilevel structural equation model of within- and between-person associations among subjective responses to alcohol, craving, and laboratory alcohol self-administration.

Jeffrey D Wardell, Vijay A Ramchandani, Christian S Hendershot

Open access · hybridAbstract read
In one paragraph

Article in Journal of abnormal psychology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 32 citations in OpenAlex.

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  13. Craving, stimulation, and sedation as predictors of alcohol demand under intoxication.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2022
    Article
  14. Exploring regulation and function of dopamine D3 receptors in alcohol use disorder. A PET [Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021
    Article
  15. Review
  16. Article
  17. Article
  18. Subjective Effects of Alcohol Predict Alcohol Choice in Social Drinkers.Alcoholism, clinical and experimental research · 2020
    Article
  19. Article
  20. To Infuse or Ingest in Human Laboratory Alcohol Research.Alcoholism, clinical and experimental research · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 3 countries.

Jeffrey D WardellCampbell Family Mental Health Research Institute, Centre for Addiction and Mental Health.
Vijay A RamchandaniSection on Human Psychopharmacology, Laboratory of Clinical and Translational Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health.
Christian S HendershotCampbell Family Mental Health Research Institute, Centre for Addiction and Mental Health Toronto.
Centre for Addiction and Mental Health · CANational Institute on Alcohol Abuse and Alcoholism · US

Funding

Translational Research and Science Education (OUT)P60AA007611 · NIAAA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI DAVID A. KAREKEN · 2003 to 2026
$45.5M
Alcohol Pharmacokinetics and Pharmacodynamics in HumansZIAAA000466 · NIAAA · NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM · PI RAMCHANDANI, VIJAY ARJUN · 2009 to 2025
$31.2M
RAT RESEARCH COMPONENTP50AA007611 · NIAAA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI BOSRON, WILLIAM F · 1987 to 2002
$5.3M
CIHR 119444-1CIHR 130189-1CIHR MFE-140817CIHR MOP-119444CIHR MSH-130189NIAAA NIH HHS P50 AA007611NIAAA NIH HHS P60 AA007611
6 · The paper itself

Abstract

Subjective responses to alcohol are important determinants of drinking behavior and have been linked with risk for alcohol use disorders. However, few attempts have been made to examine proximal within-person associations among state changes in subjective responses and ongoing alcohol self-administration in the laboratory. This study disaggregated within- and between-person associations among subjective responses and alcohol self-administration, while also examining the mediating role of craving and the moderating role of trait impaired control over alcohol. Sixty young heavy drinkers (mean age = 19.90, SD = 0.86) completed self-report measures including the Impaired Control Scale, then participated in a 2-hr intravenous alcohol self-administration session using the Computer-Assisted Self-infusion of Ethanol (CASE) paradigm. Repeated assessments of subjective stimulation, subjective sedation, and craving were examined in relation to ongoing in-session self-administration, as indexed by breath alcohol concentration (BrAC) assessed 15 min later. Multilevel structural equation modeling was used to isolate within-person and between-person associations. The results showed few significant associations at the between-person level, except for a direct negative association between sedation and BrAC. At the within-person level, state fluctuations in stimulation were positively associated with both craving and subsequent BrAC, whereas state changes in sedation were negatively associated with craving and positively associated with BrAC. Within-person indirect associations from subjective stimulation and sedation to subsequent BrAC mediated via craving were statistically significant. Also, participants higher on impaired control showed stronger within-person associations between craving and greater subsequent BrAC. The results suggest that subjective responses to alcohol and craving have proximal associations with self-administration behavior, the strength of which is linked with trait impaired control over alcohol.

Indexed as

Models, TheoreticalAlcohol DrinkingCravingEthanolFemaleHumansMaleSelf AdministrationYoung AdultEthanol

Identifiers

PMID26595481
PMCPMC5266598
OpenAlexW2263154186

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.