ArticleJournal of abnormal psychology2015
Predicting first onset of depression in young girls: Interaction of diurnal cortisol and negative life events.
Article in Journal of abnormal psychology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Psychological and contextual risk factors for first-onset depression among adolescents and young people around the globe: A systematic review and meta-analysis.Early intervention in psychiatry · 2023Pooled it
- Colon-delivered short-chain fatty acids attenuate the cortisol response to psychosocial stress in healthy men: a randomized, placebo-controlled trial.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Trial
- Risk factors that predict future onset of each DSM-5 eating disorder: Predictive specificity in high-risk adolescent females.Journal of abnormal psychology · 2017Trial
- Adaptation to Preceding Acute Psychological Stress is Associated With Subsequent Stress Coping Levels via Corticoid Receptors.Alpha psychiatry · 2025Article
- Unraveling the Complex Interplay Between Neuroinflammation and Depression: A Comprehensive Review.International journal of molecular sciences · 2025Review
- Child Maltreatment and Psychopathology: A Brief Review on the Potential Role of the Hypothalamic-pituitary-adrenal Axis.Current pediatric reviews · 2025Review
- Life stress influences the relationship between sex hormone fluctuation and affective symptoms in peripubertal female adolescents.Development and psychopathology · 2024Article
- Biological sensitivity to adolescent-parent discrepancies in perceived parental warmth.Comprehensive psychoneuroendocrinology · 2023Article
- ADHD symptoms and diurnal cortisol in adolescents: The importance of comorbidities.Psychoneuroendocrinology · 2023Article
- Multi-level predictors of depression symptoms in the Adolescent Brain Cognitive Development (ABCD) study.Journal of child psychology and psychiatry, and allied disciplines · 2022Article
- Chemiluminescent immunoassay overestimates hormone concentrations and obscures testosterone sex differences relative to LC-MS/MS in a field study of diverse adolescents.Comprehensive psychoneuroendocrinology · 2022Article
- Assessing the role of adolescent hormonal contraceptive use on risk for depression: a 3-year longitudinal study protocol.BMC women's health · 2022Article
- The Mediating and Moderating Roles of Life Skills and Cortisol in the Relationship Between Sleep Quality and Depressive Symptoms Among Chinese Adolescents With Childhood Household Dysfunction.Frontiers in psychiatry · 2022Article
- Childhood Trauma, the HPA Axis and Psychiatric Illnesses: A Targeted Literature Synthesis.Frontiers in psychiatry · 2022Review
- Testosterone, estradiol, DHEA and cortisol in relation to anxiety and depression scores in adolescents.Journal of affective disorders · 2021Article
- Hair glucocorticoids in adults with intellectual disabilities and depressive symptoms pre- and post-bright light therapy: First explorations.Journal of applied research in intellectual disabilities : JARID · 2021Article
- miR-218 in Adolescence Predicts and Mediates Vulnerability to Stress.Biological psychiatry · 2021Article
- Developmental pathways from preschool irritability to multifinality in early adolescence: the role of diurnal cortisol.Psychological medicine · 2021Article
- Differential Susceptibility to the Impact of the COVID-19 Pandemic on Working Memory, Empathy, and Perceived Stress: The Role of Cortisol and Resilience.Brain sciences · 2021Article
- The prevalence of behavioral and emotional problems among Chinese school children and adolescents aged 6-16: a national survey.European child & adolescent psychiatry · 2021Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Interactions between biological vulnerability and environmental adversity are central to the pathophysiology of depression. Given evidence that the hypothalamic-pituitary-adrenal (HPA) axis influences biological responses to environmental events, in the current longitudinal study the authors examined HPA-axis functioning, negative life events, and their interaction as predictors of the first onset of depression. At baseline, girls ages 9 to 14 years provided saliva samples to assess levels of diurnal cortisol production, quantified by total cortisol production (area under the curve with respect to ground; AUCg) and the cortisol awakening response (CAR). The authors then followed these participants until they reached age 18 in order to assess their subsequent experience of negative life events and the onset of a depressive episode. They found that the influence of negative life events on the subsequent onset of depression depended on HPA-axis functioning at baseline. Specifically, negative life events predicted the onset of depression in girls with higher levels of AUCg, but not in girls with lower levels of AUCg. In contrast, CAR did not predict the onset of depression either alone or in interaction with negative life events. These findings suggest that elevated total cortisol production in daily life potentiates susceptibility to environmental adversity and signals the need for early intervention.
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