Decline in Bone Mass During Weight Loss: A Cause for Concern?

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

21 citing papers in PubMed, 2 syntheses or guidelines pooled it.

1. The utility of dried blood spot measurement of bone turnover markers in biological anthropology.American journal of human biology : the official journal of the Human Biology Council · 2022
   Pooled it
2. Health Effects of Alternate-Day Fasting in Adults: A Systematic Review and Meta-Analysis.Frontiers in nutrition · 2020
   Pooled it
3. Obesity and Metabolic Disease Impair the Anabolic Response to Protein Supplementation and Resistance Exercise: A Retrospective Analysis of a Randomized Clinical Trial with Implications for Aging, Sarcopenic Obesity, and Weight Management.Nutrients · 2024
   Trial
4. Short-term time-restricted feeding is safe and feasible in non-obese healthy midlife and older adults.GeroScience · 2020
   Trial
5. Effect of Aerobic or Resistance Exercise, or Both, on Bone Mineral Density and Bone Metabolism in Obese Older Adults While Dieting: A Randomized Controlled Trial.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2020
   Trial
6. Effect of Exercise Modality During Weight Loss on Bone Health in Older Adults With Obesity and Cardiovascular Disease or Metabolic Syndrome: A Randomized Controlled Trial.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2018
   Trial
7. Effect of testosterone treatment on bone remodelling markers and mineral density in obese dieting men in a randomized clinical trial.Scientific reports · 2018
   Trial
8. Why Do We Lose Bone During Weight Loss: Can It Be Prevented?Current osteoporosis reports · 2026
   Review
9. Effects of a Combined Dietary and Physical Activity Intervention on Bone Density, Lean Mass and Fat Mass in Adults: The GOTO Trial.Journal of cachexia, sarcopenia and muscle · 2026
   Article
10. 20% Caloric Restriction did not Impact Bone Health nor Exercise-Induced Elevations in Bone Mass in Young Female Rats.Calcified tissue international · 2026
    Article
11. Intake of eggshell membrane enhances bone mass and suppresses bone marrow adiposity in normal growing rats.Bone reports · 2025
    Article
12. Protein intake, malnutrition, and its association with bone health after a hip fracture: A 3-month prospective study.AIMS public health · 2025
    Article
13. Intermittent Fasting: Myths, Fakes and Truth on This Dietary Regimen Approach.Foods (Basel, Switzerland) · 2024
    Review
14. Relationships between longitudinal changes in body composition and bone mineral density in middle-to-older aged Australians.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2023
    Article
15. Randomized controlled trial for time-restricted eating in overweight and obese young adults.iScience · 2022
    Article
16. Secondary Osteoporosis and Metabolic Bone Diseases.Journal of clinical medicine · 2022
    Review
17. G-CSF partially mediates effects of sleeve gastrectomy on the bone marrow niche.The Journal of clinical investigation · 2019
    Article
18. Weight loss in men in late life and bone strength and microarchitecture: a prospective study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2018
    Article
19. Effects of Gastric Bypass Surgery on Bone Mass and Microarchitecture Occur Early and Particularly Impact Postmenopausal Women.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2018
    Article
20. Effects of Incretin-Based Therapies and SGLT2 Inhibitors on Skeletal Health.Current osteoporosis reports · 2016
    Review

Corrections and comments

• Comment on
  Effect of Two-Year Caloric Restriction on Bone Metabolism and Bone Mineral Density in Non-Obese Younger Adults: A Randomized Clinical Trial.2016

Authors and funding

1 author.

Funding

Abstract

PubMed holds no abstract for this paper.

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