Evidence map›Paper›PMID 26594663›Full record

ArticleCell systems2015

NDEx, the Network Data Exchange.

Dexter Pratt, Jing Chen, David Welker, Ricardo Rivas, Rudolf Pillich, Vladimir Rynkov, Keiichiro Ono, Carol Miello, Lyndon Hicks, Sandor Szalma and 6 more

Abstract read
In one paragraph

Article in Cell systems, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 155 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
155citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

155 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Target discovery and drug design in the era of artificial intelligence.Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents · 2026
    Review
  4. Article
  5. Article
  6. Mutation-informed gene pairs to predict melanoma metastasis.Cell communication and signaling : CCS · 2026
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

95 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Dexter PrattDepartment of Medicine, University of California San Diego, La Jolla, CA 92093, USA.
Jing ChenDepartment of Medicine, University of California San Diego, La Jolla, CA 92093, USA.
David WelkerDepartment of Medicine, University of California San Diego, La Jolla, CA 92093, USA.
Ricardo RivasDepartment of Medicine, University of California San Diego, La Jolla, CA 92093, USA.
Rudolf PillichDepartment of Medicine, University of California San Diego, La Jolla, CA 92093, USA.
Vladimir RynkovDepartment of Medicine, University of California San Diego, La Jolla, CA 92093, USA.
Keiichiro OnoDepartment of Medicine, University of California San Diego, La Jolla, CA 92093, USA.
Carol MielloPfizer Inc., Eastern Point Road, Groton, CT 06340, USA.
Lyndon HicksPfizer Inc., 1 Burtt Rd, Andover, MA 01810, USA.
Sandor SzalmaJanssen Research and Development LLC, 3210 Merryfield Row, San Diego, CA 92121, USA.
Aleksandar StojmirovicJanssen Research and Development LLC, 1400 McKean Road, Spring House, PA 19477, USA.
Radu DobrinJanssen Research and Development LLC, 1400 McKean Road, Spring House, PA 19477, USA.
Michael BraxenthalerRoche, Pharma Research and Early Development Informatics (pREDi), Roche Innovation Center New York, New York, 10016, USA.
Jan KuentzerRoche, Pharma Research and Early Development Informatics (pREDi), Roche Innovation Center Penzberg, Penzberg, 82377, Germany.
Barry DemchakDepartment of Medicine, University of California San Diego, La Jolla, CA 92093, USA.
Trey IdekerDepartment of Medicine, University of California San Diego, La Jolla, CA 92093, USA ; Department of Computer Science and Engineering, University of California San Diego, La Jolla, CA 92093, USA.

Funding

Cytoscape: A Modeling Platform for Biomolecular NetworksR01GM070743 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI IDEKER, TREY · 2004 to 2016
$5.7M
NDEx - the Network Data Exchange A Network Commons for BiologistsU24CA184427 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PRATT, DEXTER · 2014 to 2021
$5.7M
NCI NIH HHS U24 CA184427NIGMS NIH HHS R01 GM070743
6 · The paper itself

Abstract

Networks are a powerful and flexible methodology for expressing biological knowledge for computation and communication. Network-encoded information can include systematic screens for molecular interactions, biological relationships curated from literature, and outputs from analysis of Big Data. NDEx, the Network Data Exchange (www.ndexbio.org), is an online commons where scientists can upload, share, and publicly distribute networks. Networks in NDEx receive globally unique accession IDs and can be stored for private use, shared in pre-publication collaboration, or released for public access. Standard and novel data formats are accommodated in a flexible storage model. Organizations can use NDEx as a distribution channel for networks they generate or curate. Developers of bioinformatic applications can store and query NDEx networks via a common programmatic interface. NDEx helps expand the role of networks in scientific discourse and facilitates the integration of networks as data in publications. It is a step towards an ecosystem in which networks bearing data, hypotheses, and findings flow easily between scientists.

Identifiers

PMID26594663
PMCPMC4649937

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.