ArticleNeuroImage. Clinical2015
Evidence of multisensory plasticity: Asymmetrical medial geniculate body in people with one eye.
Article in NeuroImage. Clinical, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 15 citations in OpenAlex.
- Pulvinar and total thalamus volumes are preserved following early monocular enucleation.Frontiers in neuroscience · 2026Article
- Perception of the McGurk effect in people with one eye depends on whether the eye is removed during infancy or adulthood.Frontiers in neuroscience · 2023Article
- Altered Spontaneous Brain Activity and Network Property in Patients With Congenital Monocular Blindness.Frontiers in neurology · 2022Article
- Review
- Improving the Quantification of the Lateral Geniculate Nucleus in Magnetic Resonance Imaging Using a Novel 3D-Edge Enhancement Technique.Frontiers in computational neuroscience · 2021Article
- Brain Activation for Audiovisual Information in People With One Eye Compared to Binocular and Eye-Patched Viewing Controls.Frontiers in neuroscience · 2020Article
- Modulation of tonotopic ventral medial geniculate body is behaviorally relevant for speech recognition.eLife · 2019Article
- Altered white matter structure in auditory tracts following early monocular enucleation.NeuroImage. Clinical · 2019Article
- Altered white matter structure in the visual system following early monocular enucleation.Human brain mapping · 2018Article
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
unlabelledThe medial geniculate body (MGB) plays a central role in auditory processing with both efferent and afferent tracts to primary auditory cortex. People who have lost one eye early in life have enhanced sound localization, lack visual over auditory dominance and integrate auditory and visual information optimally, similar to controls, despite taking longer to localize unimodal visual stimuli. Compared to controls, people with one eye have decreased lateral geniculate nuclei (LGN) volume as expected given the 50% deafferentation of the visual system. However, LGN volume is larger than predicted contralateral to the remaining eye, indicating altered structural development likely through recruitment of deafferented LGN cells. PURPOSE: the current study investigated whether structural MGB changes are also present in this group given the changes they exhibit in auditory processing.
methodsMGB volumes were measured in adults who had undergone early unilateral eye enucleation and were compared to binocularly intact controls.
resultsunlike controls, people with one eye had a significant asymmetry with a larger left compared to right MGB, independent of eye of enucleation. MGB volume correlated positively with LGN volume in people with one eye.
conclusionsvolume asymmetry in the MGB in people with one eye may represent increased interactions between the left MGB and primary auditory cortex. This interaction could contribute to increased auditory and other left hemisphere-dominant processing, including language, as compensation for the loss of one half of visual inputs early in life. The positive correlation between MGB and LGN volume is not due to space constraints but rather indicates increased plasticity in both auditory and visual sensory systems following early eye enucleation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.