ArticleNeuroImage. Clinical2015
Joint assessment of white matter integrity, cortical and subcortical atrophy to distinguish AD from behavioral variant FTD: A two-center study.
Article in NeuroImage. Clinical, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Morphometric MRI as a diagnostic biomarker of frontotemporal dementia: A systematic review to determine clinical applicability.NeuroImage. Clinical · 2018Pooled it
- Neurotransmitter-defined cerebral vulnerability patterns in frontotemporal lobar degeneration (FTLD).Journal of neurology · 2026Article
- Discriminating behavioral variant frontotemporal dementia from Alzheimer's disease via the Frontal Assessment Battery.Journal of neurology · 2026Article
- Frontotemporal dementia subtyping using machine learning, multivariate statistics and neuroimaging.Brain communications · 2025Article
- Diagnostic and predictive power of plasma proteins in Alzheimer's disease: a cross-sectional and longitudinal study in China.Scientific reports · 2024Article
- Longitudinal volumetric changes in amygdala subregions in frontotemporal dementia.Journal of neurology · 2024Article
- Cortical thickness modeling and variability in Alzheimer's disease and frontotemporal dementia.Journal of neurology · 2024Article
- Frontotemporal Dementia, Where Do We Stand? A Narrative Review.International journal of molecular sciences · 2023Review
- Parkinsonism Is Associated with Altered SMA-Basal Ganglia Structural and Functional Connectivity in Frontotemporal Degeneration.Biomedicines · 2023Article
- Thalamic pathology in frontotemporal dementia: Predilection for specific nuclei, phenotype-specific signatures, clinical correlates, and practical relevance.Brain and behavior · 2023Review
- Multiclass characterization of frontotemporal dementia variants via multimodal brain network computational inference.Network neuroscience (Cambridge, Mass.) · 2023Article
- White matter alterations in the dorsal attention network contribute to a high risk of unsafe driving in healthy older people.PCN reports : psychiatry and clinical neurosciences · 2022Article
- Neurodegenerative Disorders of Alzheimer, Parkinsonism, Amyotrophic Lateral Sclerosis and Multiple Sclerosis: An Early Diagnostic Approach for Precision Treatment.Metabolic brain disease · 2022Review
- An MRI-based strategy for differentiation of frontotemporal dementia and Alzheimer's disease.Alzheimer's research & therapy · 2021Article
- Looking beneath the surface: the importance of subcortical structures in frontotemporal dementia.Brain communications · 2021Review
- Contribution of CSF biomarkers to early-onset Alzheimer's disease and frontotemporal dementia neuroimaging signatures.Human brain mapping · 2020Article
- Classification using fractional anisotropy predicts conversion in genetic frontotemporal dementia, a proof of concept.Brain communications · 2020Article
- Multimodal MRI of grey matter, white matter, and functional connectivity in cognitively healthy mutation carriers at risk for frontotemporal dementia and Alzheimer's disease.BMC neurology · 2019Article
- Longitudinal analysis of brain atrophy in Alzheimer's disease and frontotemporal dementia.The Journal of international medical research · 2019Article
- Detecting frontotemporal dementia syndromes using MRI biomarkers.NeuroImage. Clinical · 2019Article
Corrections and comments
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We investigated the ability of cortical and subcortical gray matter (GM) atrophy in combination with white matter (WM) integrity to distinguish behavioral variant frontotemporal dementia (bvFTD) from Alzheimer's disease (AD) and from controls using voxel-based morphometry, subcortical structure segmentation, and tract-based spatial statistics. To determine which combination of MR markers differentiated the three groups with the highest accuracy, we conducted discriminant function analyses. Adjusted for age, sex and center, both types of dementia had more GM atrophy, lower fractional anisotropy (FA) and higher mean (MD), axial (L1) and radial diffusivity (L23) values than controls. BvFTD patients had more GM atrophy in orbitofrontal and inferior frontal areas than AD patients. In addition, caudate nucleus and nucleus accumbens were smaller in bvFTD than in AD. FA values were lower; MD, L1 and L23 values were higher, especially in frontal areas of the brain for bvFTD compared to AD patients. The combination of cortical GM, hippocampal volume and WM integrity measurements, classified 97-100% of controls, 81-100% of AD and 67-75% of bvFTD patients correctly. Our results suggest that WM integrity measures add complementary information to measures of GM atrophy, thereby improving the classification between AD and bvFTD.
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