ArticleNeuroImage. Clinical2015
Measuring longitudinal myelin water fraction in new multiple sclerosis lesions.
Article in NeuroImage. Clinical, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Use of Noncontrast Quantitative MRI to Detect Gadolinium-Enhancing Multiple Sclerosis Brain Lesions: A Systematic Review and Meta-Analysis.AJNR. American journal of neuroradiology · 2017Pooled it
- Longitudinal myelin MR imaging in patients with multiple sclerosis: a narrative review.Journal of neurology · 2026Review
- Neurometabolite alterations in Gulf War Illness: a whole-brain magnetic resonance spectroscopy study.Experimental brain research · 2025Observational
- Repair mechanisms of the central nervous system: From axon sprouting to remyelination.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025Review
- Advanced MRI Measures of Myelin and Axon Volume Identify Repair in Multiple Sclerosis.Annals of neurology · 2024Article
- Quantifying Remyelination Using χ-Separation in White Matter and Cortical Multiple Sclerosis Lesions.Neurology · 2024Article
- Harnessing myelin water fraction as an imaging biomarker of human cerebral aging, neurodegenerative diseases, and risk factors influencing myelination: A review.Journal of neurochemistry · 2024Review
- Use of gadolinium-based contrast agents in multiple sclerosis: a review by the ESMRMB-GREC and ESNR Multiple Sclerosis Working Group.European radiology · 2024Review
- Longitudinal analysis of new multiple sclerosis lesions with magnetization transfer and diffusion tensor imaging.European radiology · 2024Article
- Bioavailable central nervous system disease-modifying therapies for multiple sclerosis.Frontiers in immunology · 2023Review
- Myelin water imaging using a short-TR adiabatic inversion-recovery (STAIR) sequence.Magnetic resonance in medicine · 2022Article
- Characterization of multiple sclerosis neuroinflammation and neurodegeneration with relaxation and diffusion basis spectrum imaging.Multiple sclerosis (Houndmills, Basingstoke, England) · 2022Article
- Multiple sclerosis plaques may undergo continuous myelin degradation: a cross-sectional study with myelin and axon-related quantitative magnetic resonance imaging metrics.Neuroradiology · 2022Article
- Lesion features on magnetic resonance imaging discriminate multiple sclerosis patients.European journal of neurology · 2022Article
- A Comparison of Magnetic Resonance Imaging Methods to Assess Multiple Sclerosis Lesions: Implications for Patient Characterization and Clinical Trial Design.Diagnostics (Basel, Switzerland) · 2021Article
- Quantitative magnetic resonance imaging towards clinical application in multiple sclerosis.Brain : a journal of neurology · 2021Review
- Microstructure of Human Corpus Callosum across the Lifespan: Regional Variations in Axon Caliber, Density, and Myelin Content.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- MRI Prognostic Factors in Multiple Sclerosis, Neuromyelitis Optica Spectrum Disorder, and Myelin Oligodendrocyte Antibody Disease.Frontiers in neurology · 2021Review
- Impact of Lesion Location on Longitudinal Myelin Water Fraction Change in Chronic Multiple Sclerosis Lesions.Journal of neuroimaging : official journal of the American Society of Neuroimaging · 2020Article
- Quantitative age-dependent differences in human brainstem myelination assessed using high-resolution magnetic resonance mapping.NeuroImage · 2020Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
objectivesInvestigating the potential of myelin repair strategies in multiple sclerosis (MS) requires an understanding of myelin dynamics during lesion evolution. The objective of this study is to longitudinally measure myelin water fraction (MWF), an MRI biomarker of myelin, in new MS lesions and to identify factors that influence their subsequent myelin content.
methodsTwenty-three MS patients were scanned with whole-brain Fast Acquisition with Spiral Trajectory and T2prep (FAST-T2) MWF mapping at baseline and median follow-up of 6 months. Eleven healthy controls (HC) confirmed the reproducibility of FAST-T2 in white matter regions of interests (ROIs) similar to a lesion size. A random-effect-model was implemented to determine the association between baseline clinical and lesion variables and the subsequent MWF.
resultsROI-based measurements in HCs were highly correlated between scans [mean r = 0.893 (.764-.967)]. In MS patients, 38 gadolinium enhancing (Gd+) and 25 new non-enhancing (Gd-) T2 hyperintense lesions (5.7 months, ±3.8) were identified. Significant improvement in MWF was seen in Gd+ lesions (0.035 ± 0.029, p < 0.001) as compared to Gd- lesions (0.006 ± 0.017, p = 0.065). In the model, a higher baseline MWF (p < 0.001) and the presence of Gd (p < 0.001) were associated with higher subsequent MWF.
conclusionsFAST T2 provides a clinically feasible method to quantify MWF in new MS lesions. The observed influence of baseline MWF, which represents a combined effect of both resolving edema and myelin change within acute lesions, suggests that the extent of initial inflammation impacts final myelin recovery.
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