Evidence map›Paper›PMID 26594618›Full record

ArticleNeuroImage. Clinical2015

A preliminary evaluation of the correlation between regional energy phosphates and resting state functional connectivity in depression.

Chun S Zuo, Pan Lin, Gordana Vitaliano, Kristina Wang, Rosemond Villafuerte, Scott E Lukas

Open access · goldAbstract readEvaluation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in NeuroImage. Clinical, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Chun S ZuoMcLean Imaging Center, McLean Hospital, Belmont, MA 02478, USA ; Harvard Medical School, Belmont, MA 02478, USA.
Pan LinMcLean Imaging Center, McLean Hospital, Belmont, MA 02478, USA ; Harvard Medical School, Belmont, MA 02478, USA.
Gordana VitalianoMcLean Imaging Center, McLean Hospital, Belmont, MA 02478, USA ; Harvard Medical School, Belmont, MA 02478, USA.
Kristina WangMcLean Imaging Center, McLean Hospital, Belmont, MA 02478, USA.
Rosemond VillafuerteMcLean Imaging Center, McLean Hospital, Belmont, MA 02478, USA.
Scott E LukasMcLean Imaging Center, McLean Hospital, Belmont, MA 02478, USA ; Harvard Medical School, Belmont, MA 02478, USA.
Imaging Center · US

Funding

Nanoengineered Neuroprobes for MRI of Dopamine Transporters in Drug AddictionK08DA037465 · NIDA · MCLEAN HOSPITAL · PI VITALIANO, GORDANA D. · 2015 to 2018
$758k
31P magnetization transfer study of bipolar disorderR21MH081076 · NIMH · MCLEAN HOSPITAL · PI ZUO, CHUN S · 2009 to 2010
$435k
NIDA NIH HHS K08 DA037465NIMH NIH HHS MH081076NIMH NIH HHS R21 MH081076
6 · The paper itself

Abstract

Impaired brain energy metabolism is among the leading hypotheses in the pathogenesis of affective disorders and linking energy phosphates with states of tissue-function activity is a novel and non-invasive approach to differentiate healthy from unhealthy states. Resting state functional MRI (fMRI) has been established as an important tool for mapping cerebral regional activity and phosphorous chemical shift imaging ((31)P CSI) has been applied to measure levels of energy phosphates and phospholipids non-invasively in order to gain insight into the possible etiology of affective disorders. This is an initial attempt to identify the existence of a correlation between regional energy phosphates and connectivity at nodes of the posterior default mode network (DMN). Resting state fMRI in conjunction with (31)P 2D CSI was applied to 11 healthy controls and 11 depressed patients at 3 T. We found that differences between the two groups exist in correlation of lateral posterior parietal cortex functional connectivity and regional Pi/PCr. Results of this study indicate that resting-state-fMRI-guided (31)P CSI can provide new insight into depression via regional energy phosphates and functional connectivity.

Indexed as

AgedBrainBrain MappingDepressive DisorderFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedPhosphatesPhosphatesCorrelationDepressionEnergy phosphatesFunctional connectivity

Identifiers

PMID26594618
PMCPMC4589842
OpenAlexW1462048611

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.