ArticleStandards in genomic sciences2015
Annotation inconsistencies beyond sequence similarity-based function prediction - phylogeny and genome structure.
Article in Standards in genomic sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it.
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- Metatranscriptomes-based sequence similarity networks uncover genetic signatures within parasitic freshwater microbial eukaryotes.Microbiome · 2025Article
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- The impact of transitive annotation on the training of taxonomic classifiers.Frontiers in microbiology · 2023Article
- Propagation, detection and correction of errors using the sequence database network.Briefings in bioinformatics · 2022Review
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- Identification of human gene research articles with wrongly identified nucleotide sequences.Life science alliance · 2022Article
- Functional characterization of prokaryotic dark matter: the road so far and what lies ahead.Current research in microbial sciences · 2022Review
- GP4: an integrated Gram-Positive Protein Prediction Pipeline for subcellular localization mimicking bacterial sorting.Briefings in bioinformatics · 2021Article
- Open Issues for Protein Function Assignment inGenes · 2021Article
- Mantis: flexible and consensus-driven genome annotation.GigaScience · 2021Article
- Leveraging Curation AmongFrontiers in microbiology · 2021Article
- Misannotations of the genes encoding sugar N-formyltransferases.Protein science : a publication of the Protein Society · 2020Article
- Homeolog expression quantification methods for allopolyploids.Briefings in bioinformatics · 2020Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The function annotation process in computational biology has increasingly shifted from the traditional characterization of individual biochemical roles of protein molecules to the system-wide detection of entire metabolic pathways and genomic structures. The so-called genome-aware methods broaden misannotation inconsistencies in genome sequences beyond protein function assignments, encompassing phylogenetic anomalies and artifactual genomic regions. We outline three categories of error propagation in databases by providing striking examples - at various levels of appreciation by the community from traditional to emerging, thus raising awareness for future solutions.
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