Evidence map›Paper›PMID 26594236›Full record

ArticleInfectious agents and cancer2015

A prospective randomized study on limits of colposcopy and histology: the skill of colposcopist and colposcopy-guided biopsy in diagnosis of cervical intraepithelial lesions.

Giuseppe Bifulco, Nicoletta De Rosa, Giada Lavitola, Roberto Piccoli, Alessandra Bertrando, Valentina Natella, Costantino Di Carlo, Luigi Insabato, Carmine Nappi

Open access · goldAbstract read
In one paragraph

Article in Infectious agents and cancer, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.4field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
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  6. Article
  7. Accuracy of colposcopy in the Swedish screening program.Acta obstetricia et gynecologica Scandinavica · 2023
    Article
  8. Observational
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  12. Value of multi-quadrants biopsy: Pooled analysis of 11 population-based cervical cancer screening studies.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2020
    Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Giuseppe Bifulco *Department of Neuroscienze e Scienze Riproduttive ed Odontostomatologiche, University of Naples "Federico II", Naples, Italy.
Nicoletta De Rosa *Department of Neuroscienze e Scienze Riproduttive ed Odontostomatologiche, University of Naples "Federico II", Naples, Italy.
Giada LavitolaDepartment of Neuroscienze e Scienze Riproduttive ed Odontostomatologiche, University of Naples "Federico II", Naples, Italy.
Roberto PiccoliDepartment of Neuroscienze e Scienze Riproduttive ed Odontostomatologiche, University of Naples "Federico II", Naples, Italy.
Alessandra BertrandoDepartment of Neuroscienze e Scienze Riproduttive ed Odontostomatologiche, University of Naples "Federico II", Naples, Italy.
Valentina NatellaDepartment of Advanced Biomedical Science, University of Naples "Federico II", Naples, Italy.
Costantino Di CarloDepartment of Neuroscienze e Scienze Riproduttive ed Odontostomatologiche, University of Naples "Federico II", Naples, Italy.
Luigi InsabatoDepartment of Advanced Biomedical Science, University of Naples "Federico II", Naples, Italy.
Carmine NappiDepartment of Sanità pubblica, University of Naples "Federico II", Naples, Italy.
University of Naples Federico II · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe main objective of our study was to evaluate the colposcopist ability to correctly identify the worst area of a cervical lesion where biopsy should be performed; the secondary objective was to investigate the influence of the colposcopist skill in grading cervical preneoplastic lesions.

methods296 patients referred for colposcopy were enrolled in a prospective study. All patients were randomized in two groups: in the first group, "senior group", the colposcopy was performed by an experienced colposcopist; in the second group, "junior group", the colposcopy was performed by a less experienced colposcopist. A detailed colposcopic description, including a grading of the lesion, was completed for each case. During the colposcopic exam patients underwent two direct biopsies; each biopsy was labeled with letter A (suspicious area with most severe grade) or B (suspicious area with less severe grade) according to the judgment of the colposcopist. An experienced pathologist reanalyzed the histological slides, after routine diagnosis.

resultsThe senior group identify the worst area of the cervical lesion in statistical significant higher rates than junior group. Specimen A resulted representative of the higher-grade lesion (A > B) in 73.7 % (N = 28) in senior group and in 48.4 % (N = 15) in junior group; while in 26.3 % (N = 10) the higher-grade lesion corresponded to specimen B (A < B) in senior group and in 51.6 % (N = 16) in junior group (p < .05).

conclusionThe ability of a colposcopist in grading cervical lesion depends on his experience.

Indexed as

Cervical intraepithelial lesionsColposcopic accuracyColposcopic gradeMultiple biopsies

Identifiers

PMID26594236
PMCPMC4653939
OpenAlexW2172492936

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.