Evidence map›Paper›PMID 26594220›Full record

ReviewFrontiers in plant science2015

Biosafety research for non-target organism risk assessment of RNAi-based GE plants.

Andrew F Roberts, Yann Devos, Godwin N Y Lemgo, Xuguo Zhou

Abstract readReview
In one paragraph

Review in Frontiers in plant science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed.

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  15. RNA-Spray-Mediated Silencing ofFrontiers in plant science · 2020
    Article
  16. Article
  17. Sublethal Endpoints in Non-target Organism Testing for Insect-Active GE Crops.Frontiers in bioengineering and biotechnology · 2020
    Review
  18. TheFrontiers in physiology · 2020
    Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Andrew F RobertsILSI Research Foundation, Center for Environmental Risk Assessment Washington, DC, USA.
Yann DevosGMO Unit, European Food Safety Authority Parma, Italy.
Godwin N Y LemgoNEPAD Agency - African Biosafety Network of Expertise Ouagadougou, Burkina Faso.
Xuguo ZhouDepartment of Entomology, College of Agriculture, Food and Environment, University of Kentucky Lexington, KY, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

RNA interference, or RNAi, refers to a set of biological processes that make use of conserved cellular machinery to silence genes. Although there are several variations in the source and mechanism, they are all triggered by double stranded RNA (dsRNA) which is processed by a protein complex into small, single stranded RNA, referred to as small interfering RNAs (siRNA) with complementarity to sequences in genes targeted for silencing. The use of the RNAi mechanism to develop new traits in plants has fueled a discussion about the environmental safety of the technology for these applications, and this was the subject of a symposium session at the 13th ISBGMO in Cape Town, South Africa. This paper continues that discussion by proposing research areas that may be beneficial for future environmental risk assessments of RNAi-based genetically modified plants, with a particular focus on non-target organism assessment.

Indexed as

biosafety researchenvironmental risk assessmentnon-target organismsplant biotechnologyRNAi

Identifiers

PMID26594220
PMCPMC4635219

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.