ArticleFrontiers in neuroscience2015
A novel versatile hybrid infusion-multielectrode recording (HIME) system for acute drug delivery and multisite acquisition of neuronal activity in freely moving mice.
Article in Frontiers in neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Dual Modulator of ASIC Channels and GABAInternational journal of molecular sciences · 2023Article
- A synthetic synaptic organizer protein restores glutamatergic neuronal circuits.Science (New York, N.Y.) · 2020Article
- The Low-Threshold Calcium Channel Cav3.2 Mediates Burst Firing of Mature Dentate Granule Cells.Cerebral cortex (New York, N.Y. : 1991) · 2018Article
- Automatic Detection of Highly Organized Theta Oscillations in the Murine EEG.Journal of visualized experiments : JoVE · 2017Article
- Heparan Sulfates Support Pyramidal Cell Excitability, Synaptic Plasticity, and Context Discrimination.Cerebral cortex (New York, N.Y. : 1991) · 2017Article
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Authors and funding
3 authors.
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Abstract
To characterize information transfer in defined brain circuits involving multiple brain regions and to evaluate underlying molecular mechanisms and their dysregulation in major brain diseases, a simple and reliable system is ultimately required for electrophysiological recording of local field potentials (LFPs, or local EEG) in combination with local delivery of drugs, enzymes and gene expression-controlling viruses near the place of recording. Here we provide a new design of a versatile reusable hybrid infusion-recording (HIME) system which can be utilized in freely moving mice performing cognitive tasks. The HIME system allows monitoring neuronal activity in multiple layers in several brain structures. Here, we provide examples of bilateral injection and recordings of full spectrum of learning and memory related oscillations, i.e., theta (4-12 Hz), gamma (40-100) and ripple activity (130-150 Hz), in five hippocampal layers as well as in the CA1 and CA2 regions. Furthermore, the system is designed to be used for parallel recordings in the amygdala, cortex and other brain areas, before and after infusion of reagents of interest, either in or off a cognitive test. We anticipate that the HIME system can be particularly convenient to advance functional neuroglycobiological studies and molecular deciphering of mechanisms governing long-term memory consolidation.
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