Evidence map›Paper›PMID 26594130›Full record

ArticleEcological indicators2013

Genetically modified whole-cell bioreporters for environmental assessment.

Tingting Xu, Dan M Close, Gary S Sayler, Steven Ripp

Abstract read
In one paragraph

Article in Ecological indicators, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Golden Gate Assembly of Aerobic and Anaerobic Microbial Bioreporters.Applied and environmental microbiology · 2022
    Article
  10. Review
  11. Article
  12. Article
  13. Whole-Cell Microbial Bioreporter for Soil Contaminants Detection.Frontiers in bioengineering and biotechnology · 2021
    Review
  14. Article
  15. Article
  16. Shifting the Specificity ofSensors (Basel, Switzerland) · 2020
    Article
  17. Article
  18. Development of a SensitiveFrontiers in microbiology · 2019
    Article
  19. Article
  20. Bacterial host and reporter gene optimization for genetically encoded whole cell biosensors.Environmental science and pollution research international · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Tingting XuThe University of Tennessee Center for Environmental Biotechnology, 676 Dabney Hall, Knoxville, TN 37996, USA.
Dan M CloseThe Joint Institute for Biological Sciences, Oak Ridge National Laboratory, PO Box 2008, MS6342 Oak Ridge, TN 37831, USA.
Gary S SaylerThe University of Tennessee Center for Environmental Biotechnology, 676 Dabney Hall, Knoxville, TN 37996, USA ; The Joint Institute for Biological Sciences, Oak Ridge National Laboratory, PO Box 2008, MS6342 Oak Ridge, TN 37831, USA.
Steven RippThe University of Tennessee Center for Environmental Biotechnology, 676 Dabney Hall, Knoxville, TN 37996, USA.

Funding

Development of Noninvasive Bioluminescence Imaging for Cancer Diagnosis and TheraR21CA127745 · NCI · UNIVERSITY OF TENNESSEE KNOXVILLE · PI SAYLER, GARY S · 2007 to 2008
$239k
NCI NIH HHS R21 CA127745
6 · The paper itself

Abstract

Living whole-cell bioreporters serve as environmental biosentinels that survey their ecosystems for harmful pollutants and chemical toxicants, and in the process act as human and other higher animal proxies to pre-alert for unfavorable, damaging, or toxic conditions. Endowed with bioluminescent, fluorescent, or colorimetric signaling elements, bioreporters can provide a fast, easily measured link to chemical contaminant presence, bioavailability, and toxicity relative to a living system. Though well tested in the confines of the laboratory, real-world applications of bioreporters are limited. In this review, we will consider bioreporter technologies that have evolved from the laboratory towards true environmental applications, and discuss their merits as well as crucial advancements that still require adoption for more widespread utilization. Although the vast majority of environmental monitoring strategies rely upon bioreporters constructed from bacteria, we will also examine environmental biosensing through the use of less conventional eukaryotic-based bioreporters, whose chemical signaling capacity facilitates a more human-relevant link to toxicity and health-related consequences.

Indexed as

BioluminescenceBioremediationBioreporterEcotoxicologyFluorescence

Identifiers

PMID26594130
PMCPMC4649933

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.