ArticleSaudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society2015
Antiproliferative effects of aspirin and diclofenac against the growth of cancer and fibroblast cells: In vitro comparative study.
Article in Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 44 citations in OpenAlex.
- Effects of Microstructured and Anti-Inflammatory-Coated Cochlear Implant Electrodes on Fibrous Tissue Growth and Neuronal Survival.Journal of functional biomaterials · 2025Article
- Optimization of Diclofenac-Loaded Bicomponent Nanofibers: Effect of Gelatin on In Vitro and In Vivo Response.Pharmaceutics · 2024Article
- The Influence of Novel, Biocompatible, and Bioresorbable Poly(3-hydroxyoctanoate) Dressings on Wound Healing in Mice.International journal of molecular sciences · 2022Article
- Development and Challenges of Diclofenac-Based Novel Therapeutics: Targeting Cancer and Complex Diseases.Cancers · 2022Review
- Unboxing the molecular modalities of mutagens in cancer.Environmental science and pollution research international · 2022Review
- Effects of Non-Opioid Analgesics on the Cell Membrane of Skin and Gastrointestinal Cancers.International journal of molecular sciences · 2022Review
- Assessment of Physicochemical, Microbiological and Toxicological Hazards at an Illegal Landfill in Central Poland.International journal of environmental research and public health · 2022Article
- PLLA Coating of Active Implants for Dual Drug Release.Molecules (Basel, Switzerland) · 2022Article
- Repositioning of Anti-Inflammatory Drugs for the Treatment of Cervical Cancer Sub-Types.Frontiers in pharmacology · 2022Article
- Controlling Inflammation Pre-Emptively or at the Time of Cutaneous Injury Optimises Outcome of Skin Scarring.Frontiers in immunology · 2022Review
- Promising Hybrids Derived from S-Allylcysteine and NSAIDs Fragments against Colorectal Cancer: Synthesis,Iranian journal of pharmaceutical research : IJPR · 2021Article
- Diclofenac Embedded in Silk Fibroin Fibers as a Drug Delivery System.Materials (Basel, Switzerland) · 2020Article
- Comparison of metamizole and paracetamol effects on colonic anastomosis and fibroblast activities in Wistar rats.BMC pharmacology & toxicology · 2020Article
- The Roles of Inflammation in Keloid and Hypertrophic Scars.Frontiers in immunology · 2020Review
- Targeting Mitochondrial Singlet Oxygen Dynamics Offers New Perspectives for Effective Metabolic Therapies of Cancer.Frontiers in oncology · 2020Review
- Controlled and tuneable drug release from electrospun fibers and a non-invasive approach for cytotoxicity testing.Scientific reports · 2019Article
- Side effects of frequently used oral antidiabetics on wound healing in vitro.Naunyn-Schmiedeberg's archives of pharmacology · 2019Article
- Metabolic therapies inhibit tumor growth in vivo and in silico.Scientific reports · 2019Article
- Diclofenac induced apoptosis via altering PI3K/Akt/MAPK signaling axis in HCT 116 more efficiently compared to SW480 colon cancer cells.Molecular biology reports · 2018Article
- Do Platelets Inhibit the Effect of Aspirin on Cancer Cells?Cancer microenvironment : official journal of the International Cancer Microenvironment Society · 2015Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Non-steroidal anti-inflammatory drugs (NSAIDs) inhibit the growth of several cancer cell lines. The aim of this study is to compare the cytotoxic effect of aspirin with diclofenac on the growth of HeLa cell, mammary cell carcinoma, rhabdomyosarcoma and fibroblast cell lines in the culture media. The cells are cultured in RPMI-1640 culture media supplemented with 5% fetal calf serum and antibiotics. Aspirin (5 mg/well) and diclofenac (0.625 mg/well) significantly inhibit the growth of HeLa, rhabdomyosarcoma and fibroblast cells. The cytotoxic effect of aspirin against rhabdomyosarcoma is significantly (p < 0.001) higher than that of diclofenac with a potency approximated 2.6. It concludes that aspirin and diclofenac inhibit the growth of fibroblast and cancer cell by inhibiting the up-regulation of cyclooxygenases enzymes in cancer cells. Aspirin is more effective than diclofenac against the growth of rhabdomyosarcoma cell line.
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