Evidence map›Paper›PMID 26594066›Full record

ArticleTetrahedron letters2015

Preparation of a conjugation-ready thiol responsive molecular switch.

Brandon Tautges, Victor Or, Joel Garcia, Jared T Shaw, Angelique Y Louie

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Tetrahedron letters, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Brandon TautgesDepartment of Chemistry, University of California at Davis, One Shields Ave, Davis, California 95616, United States.
Victor OrDepartment of Chemistry, University of California at Davis, One Shields Ave, Davis, California 95616, United States.
Joel GarciaDepartment of Biomedical Engineering, University of California at Davis, One Shields Ave, Davis, California 95616, United States.
Jared T ShawDepartment of Chemistry, University of California at Davis, One Shields Ave, Davis, California 95616, United States.
Angelique Y LouieDepartment of Biomedical Engineering, University of California at Davis, One Shields Ave, Davis, California 95616, United States.

Funding

Multimodal mPET &mMRI Imaging InstrumentationR01EB000993 · NIBIB · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI CHERRY, SIMON R, JACOBS, RUSSELL E · 2004 to 2013
$9.2M
ACQUISITION OF 500 MHZ NMR SPECTROMETERS10RR011973 · NCRR · UNIVERSITY OF CALIFORNIA DAVIS · PI LA MAR, GERD N · 1997 to 1997
–
NCRR NIH HHS S10 RR011973NIBIB NIH HHS R01 EB000993
6 · The paper itself

Abstract

In this work we synthesize molecular switches that are responsive to cysteine, homocysteine, and glutathione; three redox systems that make up the majority of the body's antioxidant defenses. Synthesized spiropyran isomers with conjugation-ready linkages showed good selectivity of response to these major antioxidant thiols over nucleophilic amino acids; however the position of the linking group can affect selectivity and reversibility of the switching response. An isomer with selectivity for cysteine against GSH and Hcy was identified.

Indexed as

Colorimetric SensorSpiropyranThiol

Identifiers

PMID26594066
PMCPMC4649948

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.