Evidence map›Paper›PMID 26594065›Full record

ArticleTetrahedron letters2015

Preparation of a 1,2-isoxazolidine synthon for the synthesis of zetekitoxin AB.

Srinivas R Paladugu, Ryan E Looper

Abstract read
In one paragraph

Article in Tetrahedron letters, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Macrocycles of Saxitoxin: Insights into the Structure of Zetekitoxin AB.Chembiochem : a European journal of chemical biology · 2025
    Article
  2. Review
  3. Article
  4. Natural Voltage-Gated Sodium Channel Ligands: Biosynthesis and Biology.Chembiochem : a European journal of chemical biology · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Srinivas R PaladuguDepartment of Chemistry, University of Utah, 315 South 1400 East, Salt Lake City, UT 84112.
Ryan E LooperDepartment of Chemistry, University of Utah, 315 South 1400 East, Salt Lake City, UT 84112.

Funding

Synthetic and biological investigations of 2-aminoimidazole derived natural products.R01GM090082 · NIGMS · UNIVERSITY OF UTAH · PI LOOPER, RYAN EDWARD · 2010 to 2019
$2.6M
NIGMS NIH HHS R01 GM090082
6 · The paper itself

Abstract

A synthesis of the 1,2-isoxazolidine fragment of the potent voltage gated sodium channel blocker, zetekitoxin AB is described. The synthesis utilizes an intramolecular nitrone -olefin 1,3-dipolar cycloaddition to establish the stereochemistry of the

Indexed as

1,2-isoxazolidinedipolar cycloadditionnitronesaxitoxinZetikitoxin AB

Identifiers

PMID26594065
PMCPMC4649947

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.