Evidence map›Paper›PMID 26594056›Full record

ArticleEuropean polymer journal2015

Hydrogel microparticles for biosensing.

Gaelle C Le Goff, Rathi L Srinivas, W Adam Hill, Patrick S Doyle

Abstract read
In one paragraph

Article in European polymer journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Review
  6. Lab on a Particle Technologies.Analytical chemistry · 2024
    Review
  7. Preparation of Amino-Functionalized Poly(Gels (Basel, Switzerland) · 2023
    Article
  8. Engineered biomimetic micro/nano-materials for tissue regeneration.Frontiers in bioengineering and biotechnology · 2023
    Review
  9. Article
  10. Hydrogel-Based Biosensors.Gels (Basel, Switzerland) · 2022
    Review
  11. Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Article
  17. Microscale Interfacial Polymerization on a Chip.Angewandte Chemie (International ed. in English) · 2021
    Article
  18. Article
  19. Article
  20. Assessing monocyte phenotype in poly(Biomedical materials (Bristol, England) · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Gaelle C Le GoffNovartis Institutes for Biomedical Research, 250 Massachusetts Avenue, Cambridge 02139, USA ; Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.
Rathi L SrinivasDepartment of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.
W Adam HillNovartis Institutes for Biomedical Research, 250 Massachusetts Avenue, Cambridge 02139, USA.
Patrick S DoyleDepartment of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.

Funding

High-throughput, Multiplexed Detection of miRNA Biomarkers in Single Cancer CellsR21CA177393 · NCI · YALE UNIVERSITY · PI DOYLE, PATRICK S, FAN, RONG · 2013 to 2015
$691k
NCI NIH HHS R21 CA177393
6 · The paper itself

Abstract

Due to their hydrophilic, biocompatible, and highly tunable nature, hydrogel materials have attracted strong interest in the recent years for numerous biotechnological applications. In particular, their solution-like environment and non-fouling nature in complex biological samples render hydrogels as ideal substrates for biosensing applications. Hydrogel coatings, and later, gel dot surface microarrays, were successfully used in sensitive nucleic acid assays and immunoassays. More recently, new microfabrication techniques for synthesizing encoded particles from hydrogel materials have enabled the development of hydrogel-based suspension arrays. Lithography processes and droplet-based microfluidic techniques enable generation of libraries of particles with unique spectral or graphical codes, for multiplexed sensing in biological samples. In this review, we discuss the key questions arising when designing hydrogel particles dedicated to biosensing. How can the hydrogel material be engineered in order to tune its properties and immobilize bioprobes inside? What are the strategies to fabricate and encode gel particles, and how can particles be processed and decoded after the assay? Finally, we review the bioassays reported so far in the literature that have used hydrogel particle arrays and give an outlook of further developments of the field.

Indexed as

biosensorhydrogelmicroparticlemultiplex assay

Identifiers

PMID26594056
PMCPMC4648376

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.