ArticleNeuropsychologia2016
Impairments in precision, rather than spatial strategy, characterize performance on the virtual Morris Water Maze: A case study.
Article in Neuropsychologia, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
49 citing papers in PubMed.
- Hippocampal CA1 gamma power predicts the precision of spatial memory judgments.Proceedings of the National Academy of Sciences of the United States of America · 2018Trial
- Neuroactive Pollution Disrupts Cognition in Fish by Causing Sex-Specific Effects on Spatial Learning.Environmental science & technology · 2026Article
- Virtual Morris Water Task: Procedures and Protocols for the Assessment of Spatial Navigation and Memory.Current protocols · 2026Article
- Spatial navigation strategy in older adults: Preference or ability?Psychology and aging · 2025Article
- Developmental exposure to legacy environmental contaminants, medial temporal lobe volumes and spatial navigation memory in late adolescents.Environmental research · 2025Article
- The hippocampus supports precise memory for public events regardless of their remoteness.Neuropsychologia · 2024Article
- Combining patient-lesion and big data approaches to reveal hippocampal contributions to spatial memory and navigation.iScience · 2024Article
- The role of recollection, familiarity, and the hippocampus in episodic and working memory.Neuropsychologia · 2024Article
- Tests for learning and memory in rodent regulatory studies.Current research in toxicology · 2024Article
- Evidence of Impaired Remote Experience-near Semantic Memory in Medial Temporal Lobe Amnesia.Journal of cognitive neuroscience · 2023Article
- Extended trajectory of spatial memory errors in typical and atypical development: The role of binding and precision.Hippocampus · 2023Article
- Spatial navigation and memory: A review of the similarities and differences relevant to brain models and age.Neuron · 2023Review
- VR for Cognition and Memory.Current topics in behavioral neurosciences · 2023Review
- An fMRI analysis of verbal and non-verbal working memory in people with a past history of opioid dependence.Frontiers in neuroscience · 2023Article
- Intact high-resolution working memory binding in a patient with developmental amnesia and selective hippocampal damage.Hippocampus · 2022Article
- Episodic memory processes modulate how schema knowledge is used in spatial memory decisions.Cognition · 2022Article
- Largely intact memory for spatial locations during navigation in an individual with dense amnesia.Neuropsychologia · 2022Article
- The Structure of Systematicity in the Brain.Current directions in psychological science · 2022Article
- Visual Dysfunction after Repetitive Mild Traumatic Brain Injury in a Mouse Model and Ramifications on Behavioral Metrics.Journal of neurotrauma · 2021Article
- Perspective taking and systematic biases in object location memory.Attention, perception & psychophysics · 2021Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Damage to the medial temporal lobes produces profound amnesia, greatly impairing the ability of patients to learn about new associations and events. While studies in rodents suggest a strong link between damage to the hippocampus and the ability to navigate using distal landmarks in a spatial environment, the connection between navigation and memory in humans remains less clear. Past studies on human navigation have provided mixed findings about whether patients with damage to the medial temporal lobes can successfully acquire and navigate new spatial environments, possibly due, in part, to issues related to patient demographics and characterization of medial temporal lobe damage. Here, we report findings from a young, high functioning patient who suffered severe medial temporal lobe damage. Although the patient is densely amnestic, her ability to acquire and utilize new, but coarse, spatial "maps" appears largely intact. Specifically, a novel computational analysis focused on the precision of her spatial search revealed a significant deficit in spatial precision rather than spatial search strategy. These findings argue that an intact hippocampus in humans is not necessary for representing multiple external landmarks during spatial navigation of new environments. We suggest instead that the human hippocampus may store and represent complex high-resolution bindings of features in the environment as part of a larger role in perception, memory, and navigation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.