Evidence map›Paper›PMID 26593896›Full record

ArticleMolecules (Basel, Switzerland)2015

Agrimonia eupatoria L. and Cynara cardunculus L. Water Infusions: Phenolic Profile and Comparison of Antioxidant Activities.

Anika Kuczmannová, Peter Gál, Lenka Varinská, Jakub Treml, Ivan Kováč, Martin Novotný, Tomáš Vasilenko, Stefano Dall'Acqua, Milan Nagy, Pavel Mučaji

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Food science & nutrition · 2025
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  2. Assessment ofBiomolecules · 2024
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  6. Metabolite Profiling of "Green" Extracts ofMolecules (Basel, Switzerland) · 2022
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  7. The Aerial Parts ofMolecules (Basel, Switzerland) · 2021
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. In vivo (Athens, Greece)
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Anika KuczmannováDepartment of Pharmacognosy and Botany, Faculty of Pharmacy, Comenius University, Odbojárov 10, 832 32 Bratislava, Slovakia. kuczmannova@fpharm.uniba.com.
Peter GálDepartment of Pharmacognosy and Botany, Faculty of Pharmacy, Comenius University, Odbojárov 10, 832 32 Bratislava, Slovakia. mucaji@fpharm.uniba.sk.
Lenka VarinskáDepartment of Pharmacology, Faculty of Medicine, Pavol Jozef Šafárik University, Trieda SNP 1, 040 11 Košice, Slovakia. lenka.varinska@upjs.sk.
Jakub TremlDepartment of Molecular Biology and Pharmaceutical Biotechnology, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, Palackého 1-3, 612 42 Brno, Czech Republic. tremlj@vfu.cz.
Ivan KováčDepartment for Biomedical Research, East-Slovak Institute of Cardiovascular Diseases, Inc., Ondavská 8, 040 11 Košice, Slovakia. ivankovac.kovi@gmail.com.
Martin NovotnýDepartment for Biomedical Research, East-Slovak Institute of Cardiovascular Diseases, Inc., Ondavská 8, 040 11 Košice, Slovakia. martin.novotny.dr@gmail.com.
Tomáš VasilenkoDepartment for Biomedical Research, East-Slovak Institute of Cardiovascular Diseases, Inc., Ondavská 8, 040 11 Košice, Slovakia. tomasvasilenko@gmail.com.
Stefano Dall'AcquaDepartment of Pharmaceutical and Pharmacological Sciences, University of Padova, Via F. Marzolo 5, 351 31 Padova, Italy. stefano.dallacqua@unipd.it.
Milan NagyDepartment of Pharmacognosy and Botany, Faculty of Pharmacy, Comenius University, Odbojárov 10, 832 32 Bratislava, Slovakia. nagy@fpharm.uniba.sk.
Pavel MučajiDepartment of Pharmacognosy and Botany, Faculty of Pharmacy, Comenius University, Odbojárov 10, 832 32 Bratislava, Slovakia. pgal@vusch.sk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Reactive oxygen species (ROS) are highly considered in the ethiopathogenesis of different pathological conditions because they may cause significant damage to cells and tissues. In this paper, we focused on potential antioxidant properties of two medical plants such as the Agrimonia eupatoria L. and Cynara cardunculus L. Both plants have previously been studied for their pharmacological activities, especially as hepatoprotective and hypoglycemic activities. It has been suggested, that their effects are related to the antioxidant properties of polyphenols, which are dominant compounds of the plants' extracts. In the present study HPLC-MS analysis of water infusion was performed allowing the identification of several phenolic constituents. Furthermore, antioxidant effects of the two extracts were compared showing higher effects for agrimony extract compared to artichoke. Thus, agrimony was selected for the in vivo study using the skin flap viability model. In conclusion, our results provide evidence that the A. eupatoria extract may be a valuable source of polyphenols to be studied for the future development of supplements useful in the prevention of diseases linked to oxidative stress.

Indexed as

AgrimoniaAnimalsAntioxidantsCatalaseCell LineCell SurvivalChromatography, High Pressure LiquidCynaraDNA DamageHumansOxidative StressPhenolsPlant ExtractsRatsReactive Oxygen SpeciesSuperoxide DismutaseAntioxidantsCatalasePhenolsPlant ExtractsReactive Oxygen SpeciesSuperoxide Dismutaseagrimonyantioxidantsartichokeoxidative stressROS

Identifiers

PMID26593896
PMCPMC6332114

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.