ArticleJournal of biomechanical engineering2016
Computationally Optimizing the Compliance of a Biopolymer Based Tissue Engineered Vascular Graft.
Article in Journal of biomechanical engineering, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Long-term remodeling of compliance matched tissue engineered vascular grafts is sex specific.Acta biomaterialia · 2026Article
- Hemodynamics and Wall Mechanics of Vascular Graft Failure.Arteriosclerosis, thrombosis, and vascular biology · 2024Review
- Acute Elution of TGFβ2 Affects the Smooth Muscle Cells in a Compliance-Matched Vascular Graft.Tissue engineering. Part A · 2022Article
- In vivo development of tissue engineered vascular grafts: a fluid-solid-growth model.Biomechanics and modeling in mechanobiology · 2022Article
- In-vivo assessment of a tissue engineered vascular graft computationally optimized for target vessel compliance.Acta biomaterialia · 2021Article
- Spontaneous reversal of stenosis in tissue-engineered vascular grafts.Science translational medicine · 2020Article
- Fabricating mechanically improved silk-based vascular grafts by solution control of the gel-spinning process.Biomaterials · 2020Article
- Modulating smooth muscle cell response by the release of TGFβ2 from tubular scaffolds for vascular tissue engineering.Journal of controlled release : official journal of the Controlled Release Society · 2019Article
- Building Blood Vessels with Vascular Progenitor Cells.Trends in molecular medicine · 2018Review
- Stress Analysis-Driven Design of Bilayered Scaffolds for Tissue-Engineered Vascular Grafts.Journal of biomechanical engineering · 2017Article
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Authors and funding
5 authors.
Funding
Abstract
Coronary heart disease is a leading cause of death among Americans for which coronary artery bypass graft (CABG) surgery is a standard surgical treatment. The success of CABG surgery is impaired by a compliance mismatch between vascular grafts and native vessels. Tissue engineered vascular grafts (TEVGs) have the potential to be compliance matched and thereby reduce the risk of graft failure. Glutaraldehyde (GLUT) vapor-crosslinked gelatin/fibrinogen constructs were fabricated and mechanically tested in a previous study by our research group at 2, 8, and 24 hrs of GLUT vapor exposure. The current study details a computational method that was developed to predict the material properties of our constructs for crosslinking times between 2 and 24 hrs by interpolating the 2, 8, and 24 hrs crosslinking time data. matlab and abaqus were used to determine the optimal combination of fabrication parameters to produce a compliance matched construct. The validity of the method was tested by creating a 16-hr crosslinked construct of 130 μm thickness and comparing its compliance to that predicted by the optimization algorithm. The predicted compliance of the 16-hr construct was 0.00059 mm Hg-1 while the experimentally determined compliance was 0.00065 mm Hg-1, a relative difference of 9.2%. Prior data in our laboratory has shown the compliance of the left anterior descending porcine coronary (LADC) artery to be 0.00071 ± 0.0003 mm Hg-1. Our optimization algorithm predicts that a 258-μm-thick construct that is GLUT vapor crosslinked for 8.1 hrs would match LADC compliance. This result is consistent with our previous work demonstrating that an 8-hr GLUT vapor crosslinked construct produces a compliance that is not significantly different from a porcine coronary LADC.
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Registered trials
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