Evidence map›Paper›PMID 26593266›Full record

Trial reportNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2016

Effect of the Putative Lithium Mimetic Ebselen on Brain Myo-Inositol, Sleep, and Emotional Processing in Humans.

Nisha Singh, Ann L Sharpley, Uzay E Emir, Charles Masaki, Mohammad M Herzallah, Mark A Gluck, Trevor Sharp, Catherine J Harmer, Sridhar R Vasudevan, Philip J Cowen and 1 more

2 registry-linked trialsAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 48 papers.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed
8.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03013400 phase2completednot on this mapstarted 2017, after this paper: background citation

A Randomised, Parallel Group, Double Blind, Placebo Controlled, Add on Clinical Trial to Investigate Whether the Lithium Mimetic, Ebselen, Can Reduce Symptoms of Hypomania and Mania in Bipolar Patients

TypeinterventionalSponsorUniversity of OxfordRan2017 to 2019Enrolled60ConditionsBipolar Disorder, Bipolar Disorder, ManicArmsEbselen, Placebo oral capsule
NCT05117710 phase1unknown statusnot on this mapstarted 2021, after this paper: background citation

Does the IMPase Inhibitor, Ebselen, Affect Emotional Processing and Brain Myo-inositol in Treatment-resistant Depression?

TypeinterventionalSponsorUniversity of OxfordRan2021 to 2024Enrolled50ConditionsDepressive Disorder, Treatment-ResistantArmsEbselen, Placebo
3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 100 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 3 countries.

Nisha SinghDepartment of Pharmacology, University of Oxford, Oxford, UK.ORCID 0000-0002-1312-688X
Ann L SharpleyDepartment of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK.
Uzay E EmirThe Oxford Centre for Functional MRI of the Brain, Nuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, Oxford, UK.
Charles MasakiDepartment of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK.
Mohammad M HerzallahCenter for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, Newark, NJ, USA.
Mark A GluckCenter for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, Newark, NJ, USA.
Trevor SharpDepartment of Pharmacology, University of Oxford, Oxford, UK.
Catherine J HarmerDepartment of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK.
Sridhar R VasudevanDepartment of Pharmacology, University of Oxford, Oxford, UK.
Philip J CowenDepartment of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK.
Grant C ChurchillDepartment of Pharmacology, University of Oxford, Oxford, UK.
Warneford Hospital · GBUniversity of Oxford · GBRutgers, The State University of New Jersey · USJohn Radcliffe Hospital · GB

Funding

Biotechnology and Biological Sciences Research Council BB/J021547/1Medical Research Council MR/K022202/1Medical Research Council MR/L013150/1
6 · The paper itself

Abstract

Lithium remains the gold standard in treating bipolar disorder but has unwanted toxicity and side effects. We previously reported that ebselen inhibits inositol monophosphatase (IMPase) and exhibits lithium-like effects in animal models through lowering of inositol. Ebselen has been tested in clinical trials for other disorders, enabling us to determine for the first time the effect of a blood-brain barrier-penetrant IMPase inhibitor on human central nervous system (CNS) function. We now report that in a double-blind, placebo-controlled trial with healthy participants, acute oral ebselen reduced brain myo-inositol in the anterior cingulate cortex, consistent with CNS target engagement. Ebselen decreased slow-wave sleep and affected emotional processing by increasing recognition of some emotions, decreasing latency time in the acoustic startle paradigm, and decreasing the reinforcement of rewarding stimuli. In summary, ebselen affects the phosphoinositide cycle and has CNS effects on surrogate markers that may be relevant to the treatment of bipolar disorder that can be tested in future clinical trials.

Indexed as

AdultAntioxidantsAzolesBrainCross-Over StudiesDouble-Blind MethodEmotionsFemaleHealthy VolunteersHumansInositolIsoindolesLearningLithiumMaleOrganoselenium CompoundsAntioxidantsAzolesebselenInositolIsoindolesLithiumOrganoselenium Compounds

Identifiers

PMID26593266
PMCPMC4770517
OpenAlexW2195215306

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.