ArticleAngewandte Chemie (International ed. in English)2016
Dose-Dependent Response of Personal Glucose Meters to Nicotinamide Coenzymes: Applications to Point-of-Care Diagnostics of Many Non-Glucose Targets in a Single Step.
Article in Angewandte Chemie (International ed. in English), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 104 citations in OpenAlex.
- The Personal Glucose Meter as the Measurement Principle in Point-of-Care Applications.Biosensors · 2025Review
- Extended Review Concerning the Integration of Electrochemical Biosensors into Modern IoT and Wearable Devices.Biosensors · 2024Review
- Personal glucose meters coupled with signal amplification technologies for quantitative detection of non-glucose targets: Recent progress and challenges in food safety hazards analysis.Journal of pharmaceutical analysis · 2023Review
- Rapid and Finely-Tuned Expression for Deployable Sensing Applications.Advances in biochemical engineering/biotechnology · 2023Article
- Device integration of electrochemical biosensors.Nature reviews bioengineering · 2023Review
- Overcoming Major Barriers to Developing Successful Sensors for Practical Applications Using Functional Nucleic Acids.Annual review of analytical chemistry (Palo Alto, Calif.) · 2022Review
- Recent advances of using personal glucose meter as a biosensor readout for non-glucose targets.Current analytical chemistry · 2022Article
- Point-of-Care Analyte Quantification and Digital ReadoutACS synthetic biology · 2021Article
- Biosensing with DNAzymes.Chemical Society reviews · 2021Review
- DNAzyme Amplified Aptasensing Platform for Ochratoxin A Detection Using a Personal Glucose Meter.ACS applied materials & interfaces · 2021Article
- One-tube smart genetic testing via coupling isothermal amplification and three-way nucleic acid circuit to glucometers.Analytica chimica acta · 2020Article
- Translating in vitro diagnostics from centralized laboratories to point-of-care locations using commercially-available handheld meters.Trends in analytical chemistry : TRAC · 2020Article
- Programming bulk enzyme heterojunctions for biosensor development with tetrahedral DNA framework.Nature communications · 2020Article
- Immunoassay for pathogenic bacteria using platinum nanoparticles and a hand-held hydrogen detector as transducer. Application to the detection of Escherichia coli O157:H7.Mikrochimica acta · 2019Article
- Advancing Point-of-Care Diagnostics of Metabolites Through Engineering Semisynthetic Proteins.Clinical chemistry · 2019Article
- Biocomputing for Portable, Resettable, and Quantitative Point-of-Care Diagnostics: Making the Glucose Meter a Logic-Gate Responsive Device for Measuring Many Clinically Relevant Targets.Angewandte Chemie (International ed. in English) · 2018Article
- Translating molecular detections into a simple temperature test using a target-responsive smart thermometer.Chemical science · 2018Article
- Point-of-Care Diagnostics: Recent Developments in a Connected Age.Analytical chemistry · 2017Review
- Review
- Transforming the blood glucose meter into a general healthcare meter for in vitro diagnostics in mobile health.Biotechnology advancesReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
We report a discovery that personal glucose meters (PGMs) can give a dose-dependent response to nicotinamide coenzymes, such as the reduced form of nicotinamide adenine dinucleotide (NADH). We have developed methods that take advantage of this discovery to perform one-step homogeneous assays of many non-glucose targets that are difficult to recognize by DNAzymes, aptamers, or antibodies, and without the need for conjugation and multiple steps of sample dilution, separation, or fluid manipulation. The methods are based on the target-induced consumption or production of NADH through cascade enzymatic reactions. Simultaneous monitoring of the glucose and L-lactate levels in human plasma from patients with diabetes is demonstrated and the results are comparable to those from current standard test methods. Since a large number of commercially available enzymatic assay kits utilize NADH in their detection, this discovery will allow the transformation of almost all of these clinical lab tests into POC tests that use a PGM.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.