Evidence map›Paper›PMID 26593133›Full record

ReviewClinics in chest medicine2015

The Etiologic Role of Infectious Antigens in Sarcoidosis Pathogenesis.

Lindsay J Celada, Charlene Hawkins, Wonder P Drake

Open access · greenAbstract readReview
In one paragraph

Review in Clinics in chest medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 59 citations in OpenAlex.

  1. Article
  2. Pathogenetic Mechanisms Linking Sarcoidosis to Lymphoma.International journal of molecular sciences · 2025
    Review
  3. Comparison between diffuse and partial involvement of thoracic lymph nodes on the outcome of sarcoidosis patients.Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG · 2024
    Article
  4. Article
  5. Genetics of neurosarcoidosis.Journal of neuroimmunology · 2022
    Review
  6. Article
  7. Article
  8. Article
  9. CD31Journal of thoracic disease · 2021
    Article
  10. Review
  11. Article
  12. Review
  13. Trained Innate Immunity Not Always Amicable.International journal of molecular sciences · 2019
    Review
  14. Observational
  15. Sarcoidosis in A. C. Milan (1899)?Open access Macedonian journal of medical sciences · 2018
    Article
  16. Article
  17. Article
  18. The presence of mycobacterial antigens in sarcoidosis associated granulomas.Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG · 2017
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Lindsay J CeladaDepartment of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, 1161 21st Avenue South, A2200 Medical Center North, Nashville, TN 37232, USA.
Charlene HawkinsDivision of Infectious Diseases, Department of Medicine, Vanderbilt University Medical School, 1161 21st Avenue South, A2200 Medical Center North, Nashville, TN 37232, USA.
Wonder P DrakeDepartment of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, 1161 21st Avenue South, A2200 Medical Center North, Nashville, TN 37232, USA; Division of Infectious Diseases, Department of Medicine, Vanderbilt University Medical School, 1161 21st Avenue South, A2200 Medical Center North, Nashville, TN 37232, USA. Electronic address: Wonder.Drake@vanderbilt.edu.
Vanderbilt University Medical Center · US

Funding

Immunobiology of Blood and Vascular Systems Training ProgramT32HL069765 · NHLBI · VANDERBILT UNIVERSITY · PI HAWIGER, JACK J · 2002 to 2016
$6.5M
Interdisciplinary Training Program in Lung ResearchT32HL094296 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Ray Stokes Peebles · 2008 to 2026
$6.3M
Microbial induction of sarcoidosis CD4+ T cell dysfunctionR01HL117074 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL, DRAKE, WONDER P. · 2013 to 2017
$3.8M
Mentoring in Translational Research in Interstitial Lung DiseasesK24HL127301 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Wonder P. Drake · 2016 to 2026
$1.2M
Investigation of microbial hetergeneity to sarcoidosis and AAT clinical outcomeU01HL112694 · NHLBI · VANDERBILT UNIVERSITY · PI DRAKE, WONDER P. · 2012 to 2014
$463k
NHLBI NIH HHS K24 HL127301NHLBI NIH HHS R01 HL117074NHLBI NIH HHS T32 HL069765NHLBI NIH HHS T32 HL094296NHLBI NIH HHS U01 HL112694PHS HHS U01 112694
6 · The paper itself

Abstract

Sarcoidosis is a granulomatous disease of unknown etiology, most commonly involving the lung, skin, lymph node, and eyes. Molecular and immunologic studies continue to strengthen the association of sarcoidosis with infectious antigens. Independent studies report the presence of microbial nucleic acids and proteins within sarcoidosis specimens. Complementary immunologic studies also support the role of infectious agents in sarcoidosis pathogenesis. Case reports and clinical trials have emerged regarding the efficacy of antimicrobials. They support increasing efforts to identify novel therapeutics, such as antimicrobials, that will have an impact on the observed increase in sarcoidosis morbidity and mortality.

Indexed as

Anti-Infective AgentsGranulomaHumansLungSarcoidosisAnti-Infective AgentsAntimicrobialsInfectious antigensSarcoidosis

Identifiers

PMID26593133
PMCPMC4660257
OpenAlexW2190013305

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.