ArticleNeuron2015
Distinct Eligibility Traces for LTP and LTD in Cortical Synapses.
Article in Neuron, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 133 papers.
What it found
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Who cites it
133 citing papers in PubMed.
- Trial
- Vagus nerve stimulation paired with rehabilitation for upper limb motor function after ischaemic stroke (VNS-REHAB): a randomised, blinded, pivotal, device trial.Lancet (London, England) · 2021Trial
- Instructive signals drive learning through behavioral timescale synaptic plasticity in the hippocampus and beyond.Current research in neurobiology · 2026Article
- Task-irrelevant stimuli robustly drive phasic pupil-linked arousal but only weakly affect memory formation.Scientific reports · 2026Article
- Cell-Type-Specific Synaptic Scaling Mechanisms Differentially Contribute to Associative Learning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Serotonin-endocannabinoid crosstalk selectively regulates inhibitory GABAergic inputs in the medial prefrontal cortex.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Association learning drives synaptic plasticity at feedforward synapses in somatosensory cortex.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Vagus Nerve Stimulation for Neuromodulation: Evolution from Bench to Bedside.Neurology international · 2026Article
- Distinct dopaminergic spike-timing-dependent plasticity rules are suited to different functional roles.Biological cybernetics · 2026Article
- Serotonergic modulation of excitatory synapse development and plasticity.Molecules and cells · 2026Review
- Signal-Dependent Planning Noise Reduces Task Interference by Assisting in the Formation of Stable Motor Primitives in a Neural Network Model of Muscle Coordination Learning.Neural computation · 2026Article
- Cellular and subcellular specialization enables biology-constrained deep learning.Cell reports · 2026Article
- A voltage-dependent switch underlies efficient yet specific learning and memory.Current biology : CB · 2026Article
- Brain-inspired synaptic transistors for in-situ spiking reinforcement learning with eligibility trace.Nature communications · 2026Article
- From Spontaneous Ignitions to Sensorimotor Cell Assemblies via Dopamine: A Spiking Neurocomputational Model of Infants' Hand Action Acquisition.Brain sciences · 2026Article
- Autonomic nervous system dysfunction in irritable bowel syndrome: pathophysiology and therapeutic implications.Frontiers in neuroscience · 2026Review
- Plateau potentials are instructive signals for behavioral timescale synaptic plasticity in the neocortex.bioRxiv : the preprint server for biology · 2025Article
- β-Adrenergic Receptor Activation Modulates the Induction of Complex Spike-Dependent LTP by Regulating Multiple Forms of Heterosynaptic Plasticity.Hippocampus · 2025Article
- Upregulation of CCK3R leading to the suppression of chronic seizures.Translational psychiatry · 2025Article
- Environmental Novelty Modulates Rapid Cortical Plasticity During Navigation.bioRxiv : the preprint server for biology · 2025Article
73 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
In reward-based learning, synaptic modifications depend on a brief stimulus and a temporally delayed reward, which poses the question of how synaptic activity patterns associate with a delayed reward. A theoretical solution to this so-called distal reward problem has been the notion of activity-generated "synaptic eligibility traces," silent and transient synaptic tags that can be converted into long-term changes in synaptic strength by reward-linked neuromodulators. Here we report the first experimental demonstration of eligibility traces in cortical synapses. We demonstrate the Hebbian induction of distinct traces for LTP and LTD and their subsequent timing-dependent transformation into lasting changes by specific monoaminergic receptors anchored to postsynaptic proteins. Notably, the temporal properties of these transient traces allow stable learning in a recurrent neural network that accurately predicts the timing of the reward, further validating the induction and transformation of eligibility traces for LTP and LTD as a plausible synaptic substrate for reward-based learning.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.