Evidence map›Paper›PMID 26593082›Full record

ReviewClinics in perinatology2015

Pulmonary Hypertension and Vascular Abnormalities in Bronchopulmonary Dysplasia.

Peter M Mourani, Steven H Abman

Registry-linked trialOpen access · greenAbstract readReview
In one paragraph

Review in Clinics in perinatology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03576885 (Treatment of Delayed Pulmonary Transition in Extremely Preterm Infants & Bronchopulmonary Dysplasia), which is not on this map. Cited by 107 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
107citing papers in PubMed, 1 pooled it
13.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03576885 phase1 / phase2terminatednot on this mapstarted 2019, after this paper: background citation

Treatment of Delayed Pulmonary Transition in Extremely Preterm Infants & Bronchopulmonary Dysplasia

TypeinterventionalSponsorAdventHealthRan2019 to 2023Enrolled32ConditionsPulmonary Hypertension, Bronchopulmonary DysplasiaArmsinhaled nitric oxide, Placebo
3 · Its place in the literature

Who cites it

107 citing papers in PubMed, 1 synthesis or guideline pooled it, 195 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. The role of prophylactic arginine supplementation for prevention of bronchopulmonary dysplasia in extremely preterm infants.Journal of perinatology : official journal of the California Perinatal Association · 2026
    Article
  5. Results of a pulmonary hypertension screening program for premature infants with bronchopulmonary dysplasia.Journal of perinatology : official journal of the California Perinatal Association · 2026
    Article
  6. Pulmonary hypertension and acute hypoxic respiratory failure in preterm neonates.Journal of perinatology : official journal of the California Perinatal Association · 2026
    Review
  7. ECMO use in infants with bronchopulmonary dysplasia: a literature review.Journal of perinatology : official journal of the California Perinatal Association · 2026
    Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
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  20. Review

47 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Peter M MouraniSection of Pediatric Critical Care, Pediatric Heart Lung Center, Department of Pediatrics, University of Colorado, School of Medicine, 13121 East 17th Avenue, MS8414, Aurora, CO 80045, USA. Electronic address: peter.mourani@childrenscolorado.org.
Steven H AbmanSection of Pulmonary Medicine, Pediatric Heart Lung Center, Department of Pediatrics, University of Colorado, School of Medicine, Mail Stop B395, 13123 East 16th Avenue, Aurora, CO 80045, USA.
Children's Hospital Colorado · US

Funding

Role of VEGF in Perinatal Pulmonary HypertensionR01HL068702 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI ABMAN, STEVEN HERBERT, SHEPHERD, DOUGLAS · 2001 to 2021
$6.7M
Genetic Basis for Impaired Angiogenic Signaling in BPDR01HL085703 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI ABMAN, STEVEN HERBERT · 2008 to 2012
$3.3M
Phase II Trial of Sildenafil in Newborns with Persistent Pulmonary HyptertensionU01HL102235 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI ABMAN, STEVEN HERBERT, CUTTER, GARY R · 2010 to 2010
$1.3M
Role of VEGF in Perinatal HypertensionR56HL068702 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI ABMAN, STEVEN HERBERT, SHEPHERD, DOUGLAS · 2018 to 2018
$765k
NHLBI NIH HHS HL068702NHLBI NIH HHS HL085703NHLBI NIH HHS R01 HL068702NHLBI NIH HHS R01 HL085703NHLBI NIH HHS R56 HL068702NHLBI NIH HHS U01 HL102235
6 · The paper itself

Abstract

Despite advances in the care of preterm infants, these infants remain at risk bronchopulmonary dysplasia (BPD), which results in prolonged need for supplemental oxygen, recurrent respiratory exacerbations, and exercise intolerance. Recent investigations have highlighted the important contribution of the developing pulmonary circulation to lung development, showing that these infants are also at risk for pulmonary vascular disease (PVD), including pulmonary hypertension (PH) and pulmonary vascular abnormalities. Several epidemiologic studies have delineated the incidence of PH in preterm infants and the impact on outcomes. These studies have also highlighted gaps in the understanding of PVD in BPD.

Indexed as

Administration, InhalationBronchopulmonary DysplasiaEchocardiographyEndothelium-Dependent Relaxing FactorsHumansHypertension, PulmonaryInfant, NewbornInfant, PrematureNitric OxidePulmonary CirculationVascular DiseasesEndothelium-Dependent Relaxing FactorsNitric OxideBronchopulmonary dysplasiaEchocardiogramInhaled nitric oxidePulmonary hypertensionPulmonary vascular disease

Identifiers

PMID26593082
PMCPMC5863545
OpenAlexW2103800730

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.