ArticleScientific reports2015
Plant phenolics are detoxified by prophenoloxidase in the insect gut.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 83 citations in OpenAlex.
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- Transposable elements contribute to the evolution of host shift-related genes in cactophilicGenome research · 2026Article
- Aphid adaptation to plant secondary metabolites: adaptive mechanism of resistance evolution and future prospects.Horticulture research · 2026Article
- Olive Pomace Inclusion Alters the Microbial Community of Black Soldier Fly Larvae Frass While Maintaining Fertilizer Quality.MicrobiologyOpen · 2025Article
- Dietary L-3,4-dihydroxyphenylalanine (L-DOPA) augments cuticular melanization in Anopheles mosquitos reducing their lifespan and malaria burden.Nature communications · 2025Article
- In vitro and in silico evaluation of phytocompounds from Leucaena leucocephala and Entada phaseoloides targeting DNA gyrase, topoisomerase II, AKT1.Scientific reports · 2025Article
- Potential of Eugenol for Eco-friendly Control of Aedes albopictus (Diptera: Culicidae) in an Integrated Model with Non-target Organism.Neotropical entomology · 2025Article
- From Digestion to Detoxification: Exploring Plant Metabolite Impacts on Insect Enzyme Systems for Enhanced Pest Control.Insects · 2025Review
- CRISPR/Cas9-Based Genome Editing of Fall Armyworm (Biomolecules · 2024Review
- Insights into the differences related to the resistance mechanisms to the highly toxic fruitFrontiers in physiology · 2024Article
- Genomic architecture of resistance to latania scale (H. lataniae) in kiwifruit (A. chinensis var. chinensis).BMC plant biology · 2023Article
- The gut microbiota induces melanin deposits that act as substrates forMicrobiology spectrum · 2023Article
- Plastic degradation by insect hexamerins: Near-atomic resolution structures of the polyethylene-degrading proteins from the wax worm saliva.Science advances · 2023Article
- Cuticular profiling of insecticide resistant Aedes aegypti.Scientific reports · 2023Article
- Inhibition of DPP-IV Activity and Stimulation of GLP-1 Release by Gastrointestinally Digested Black Soldier Fly Prepupae.Foods (Basel, Switzerland) · 2023Article
- Cuticular profiling of insecticide resistantbioRxiv : the preprint server for biology · 2023Article
- Article
- Wax worm saliva and the enzymes therein are the key to polyethylene degradation by Galleria mellonella.Nature communications · 2022Article
- Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plant phenolics are a group of important secondary metabolites that are toxic to many animals and insects if ingested at high concentrations. Because most insects consume plant phenolics daily, they have likely evolved the capacity to detoxify these compounds. Here, we used Drosophila melanogaster, Bombyx mori and Helicoverpa armigera as models to study the metabolism of plant phenolics by prophenoloxidases. We found that insect foreguts release prophenoloxidases into the lumen, and that the survival of prophenoloxidase-deletion mutants was impaired when fed several plant phenolics and tea extracts. Using l-DOPA as a model substrate, biochemical assays in large Lepidopteran insects demonstrated that low levels of l-DOPA are rapidly metabolized into intermediates by phenoloxidases. Feeding with excess l-DOPA showed that the metabolic intermediate 5,6-dihydroxyindole reached the hindgut either by passing directly through the midgut, or by transport through the hemolymph. In the hindgut, 5,6-dihydroxyindole was further oxidized by prophenoloxidases. Intermediates exerted no toxicity in the hemocoel or midgut. These results show that plant phenolics are not toxic to insects unless prophenoloxidase genes are lost or the levels of phenolics exceed the catalytic activity of the gut prophenoloxidases.
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