ArticleClinical oral investigations2016
Early-life factors affect risk of pain and fever in infants during teething periods.
Article in Clinical oral investigations, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 19 citations in OpenAlex.
- Oral Health Conditions of Preschool Children Among Birth Cohort Studies: A Scoping Review.Oral health & preventive dentistry · 2025Article
- Consensus statement on smoking cessation in patients with pain.Journal of anesthesia · 2022Review
- From Prescription Drugs to Natural Health Products: Medication Use in Canadian Infants.Children (Basel, Switzerland) · 2022Article
- A questionnaire-based study of Paediatric Dentists' knowledge of teething signs, symptoms and management.BDJ open · 2022Article
- The need for global safeguards for fundamental rights of children at risk of infant oral mutilation (IOM).BMJ global health · 2022Article
- Rates of exposure to environmental tobacco smoke from various indoor environments among US children and nonsmoker adolescents and adults.Environmental science and pollution research international · 2018Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimThis longitudinal study aimed to investigate the prevalence of teething-related pain and fever and the early-life factors that may affect the risk of experiencing these disturbances within the first 1.5 years of life. MATERIALS AND
methodsParticipants were recruited (n = 1033) through the Growing Up in Singapore Towards healthy Outcomes (GUSTO) birth cohort (n = 1237). Interviews were performed tri-monthly regarding the prevalence of teething pain and fever in children from 6 to 18 months of age. Crude and multivariable analyses were conducted using Poisson-log regression models.
resultsPrevalence rates for teething pain and fever were 35.5 and 49.9 % respectively. Multivariable Poisson regression analysis showed maternal second-hand tobacco smoke (SHS) exposure to increase the risk of both pain (mean ratio = 1.35; p = 0.006) and fever (mean ratio = 1.22; p = 0.025), whereas SHS exposure plus active smoking further increased risk of teething pain in the children (mean ratio = 1.89; p = 0.029). Delivery via Caesarean section increased risk of teething pain (mean ratio = 1.27; p = 0.033), while prenatal plasma vitamin D insufficiency lowered such a risk (mean ratio = 0.62; p = 0.012). Compared to Chinese infants, Indian babies exhibited lower risk of teething pain and fever (both p ≤ 0.001).
conclusionsEarly-life factors such as tobacco smoke exposure and vitamin insufficiency during pregnancy, ethnicity and childbirth via Caesarean section may significantly affect the child's susceptibility to teething-related pain and fever. CLINICAL RELEVANCE: Knowledge of prevalence and risk factors of teething disturbances may better equip primary caregivers and healthcare professionals to accurately detect teething-related local and/or systemic signs/symptoms and effectively facilitate tobacco cessation among pregnant women.
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