ArticleTheoretical population biology2016
Isolation-by-distance-and-time in a stepping-stone model.
Article in Theoretical population biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed.
- Article
- The effect of habitat loss and fragmentation on isolation by distance and divergence.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Ancient dog mitogenomes support the dual dispersal of dogs and agriculture into South America.Proceedings. Biological sciences · 2025Article
- Performance of qpAdm-based screens for genetic admixture on graph-shaped histories and stepping stone landscapes.Genetics · 2025Article
- Demographic and historical processes influencing Cochliomyia hominivorax (Diptera: Calliphoridae) population structure across South America.Parasites & vectors · 2025Article
- Landscape features influencing gene flow and connectivity of an endangered passerine.Ecology and evolution · 2024Article
- Genomic variation from an extinct species is retained in the extant radiation following speciation reversal.Nature ecology & evolution · 2022Article
- Factor analysis of ancient population genomic samples.Nature communications · 2020Article
- FHeredity · 2019Article
- Haplotype-based genotyping-by-sequencing in oat genome research.Plant biotechnology journal · 2018Article
- Human bony labyrinth is an indicator of population history and dispersal from Africa.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Statistical methods for analyzing ancient DNA from hominins.Current opinion in genetics & development · 2016Review
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
With the great advances in ancient DNA extraction, genetic data are now obtained from geographically separated individuals from both present and past. However, population genetics theory about the joint effect of space and time has not been thoroughly studied. Based on the classical stepping-stone model, we develop the theory of Isolation by distance and time. We derive the correlation of allele frequencies between demes in the case where ancient samples are present, and investigate the impact of edge effects with forward-in-time simulations. We also derive results about coalescent times in circular and toroidal models. As one of the most common ways to investigate population structure is principal components analysis (PCA), we evaluate the impact of our theory on PCA plots. Our results demonstrate that time between samples is an important factor. Ancient samples tend to be drawn to the center of a PCA plot.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.