Evidence map›Paper›PMID 26590901›Full record

ReviewCarcinogenesis2016

Cancer prevention as part of precision medicine: 'plenty to be done'.

Bernard W Stewart, Freddie Bray, David Forman, Hiroko Ohgaki, Kurt Straif, Andreas Ullrich, Christopher P Wild

Open access · hybridAbstract readReview
In one paragraph

Review in Carcinogenesis, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed, 2 pooled it
8.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 2 syntheses or guidelines pooled it, 137 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
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  5. Article
  6. Review
  7. Review
  8. Cancer prevention: the wero we are called to meet.Journal of the Royal Society of New Zealand · 2025
    Article
  9. Review
  10. Article
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  13. Review
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  19. Alpinetin: a Dietary Flavonoid with Diverse Anticancer Effects.Applied biochemistry and biotechnology · 2022
    Review
  20. Article

1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 3 countries.

Bernard W Stewart
Freddie BrayInternational Agency for Research on Cancer, 69008 Lyon, France and.
David FormanInternational Agency for Research on Cancer, 69008 Lyon, France and.
Hiroko OhgakiInternational Agency for Research on Cancer, 69008 Lyon, France and.
Kurt StraifInternational Agency for Research on Cancer, 69008 Lyon, France and.
Andreas UllrichNoncommunicable Diseases and Mental Health, World Health Organization, 1121 Geneva 27, Switzerland.
Christopher P WildInternational Agency for Research on Cancer, 69008 Lyon, France and director@iarc.fr.
Centre International de Recherche sur le Cancer · FRSouth Eastern Sydney Local Health District · AUWorld Health Organization · CH

Funding

World Health Organization 001
6 · The paper itself

Abstract

Cancer burden worldwide is projected to rise from 14 million new cases in 2012 to 24 million in 2035. Although the greatest increases will be in developing countries, where cancer services are already hard pressed, even the richest nations will struggle to meet demands of increasing patient numbers and spiralling treatment costs. No country can treat its way out of the cancer problem. Consequently, cancer control must combine improvements in treatment with greater emphasis on prevention and early detection. Cancer prevention is founded on describing the burden of cancer, identifying the causes and evaluating and implementing preventive interventions. Around 40-50% of cancers could be prevented if current knowledge about risk factors was translated into effective public health strategies. The benefits of prevention are attested to by major successes, for example, in tobacco control, vaccination against oncogenic viruses, reduced exposure to environmental and occupational carcinogens, and screening. Progress is still needed in areas such as weight control and physical activity. Fresh impetus for prevention and early detection will come through interdisciplinary approaches, encompassing knowledge and tools from advances in cancer biology. Examples include mutation profiles giving clues about aetiology and biomarkers for early detection, to stratify individuals for screening or for prognosis. However, cancer prevention requires a broad perspective stretching from the submicroscopic to the macropolitical, recognizing the importance of molecular profiling and multisectoral engagement across urban planning, transport, environment, agriculture, economics, etc., and applying interventions that may just as easily rely on a legislative measure as on a molecule.

Indexed as

Global HealthHumansNeoplasmsPrecision Medicine

Identifiers

PMID26590901
PMCPMC4700936
OpenAlexW2174994807

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.