Evidence map›Paper›PMID 26590845›Full record

ArticleEuropean archives of psychiatry and clinical neuroscience2016

EEG marker of inhibitory brain activity correlates with resting-state cerebral blood flow in the reward system in major depression.

A Cantisani, T Koenig, K Stegmayer, A Federspiel, H Horn, T J Müller, R Wiest, W Strik, S Walther

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In one paragraph

Article in European archives of psychiatry and clinical neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

A CantisaniTranslational Research Center, University Hospital of Psychiatry, University Bern, Bolligenstrasse 111, 3000, Bern 60, Switzerland. andrea.cantisani@unifi.it.
T KoenigTranslational Research Center, University Hospital of Psychiatry, University Bern, Bolligenstrasse 111, 3000, Bern 60, Switzerland.
K StegmayerTranslational Research Center, University Hospital of Psychiatry, University Bern, Bolligenstrasse 111, 3000, Bern 60, Switzerland.
A FederspielTranslational Research Center, University Hospital of Psychiatry, University Bern, Bolligenstrasse 111, 3000, Bern 60, Switzerland.
H HornTranslational Research Center, University Hospital of Psychiatry, University Bern, Bolligenstrasse 111, 3000, Bern 60, Switzerland.
T J MüllerTranslational Research Center, University Hospital of Psychiatry, University Bern, Bolligenstrasse 111, 3000, Bern 60, Switzerland.
R WiestDepartment of Diagnostic and Interventional Neuroradiology, Inselspital, University Hospital of Bern, Bern, Switzerland.
W StrikTranslational Research Center, University Hospital of Psychiatry, University Bern, Bolligenstrasse 111, 3000, Bern 60, Switzerland.
S WaltherTranslational Research Center, University Hospital of Psychiatry, University Bern, Bolligenstrasse 111, 3000, Bern 60, Switzerland.
University Hospital of Bern · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Frontal alpha band asymmetry (FAA) is a marker of altered reward processing in major depressive disorder (MDD), associated with reduced approach behavior and withdrawal. However, its association with brain metabolism remains unclear. The aim of this study was to investigate FAA and its correlation with resting-state cerebral blood flow (rCBF). We hypothesized an association of FAA with regional rCBF in brain regions relevant to reward processing and motivated behavior, such as the striatum. We enrolled 20 patients and 19 healthy subjects. FAA scores and rCBF were quantified with the use of EEG and arterial spin labeling. Correlations of the two were evaluated, as well as the association with FAA and psychometric assessments of motivated behavior and anhedonia. Patients showed a left-lateralized pattern of frontal alpha activity and a correlation of FAA lateralization with subscores of Hamilton Depression Rating Scale linked to motivated behavior. An association of rCBF and FAA scores was found in clusters in the dorsolateral prefrontal cortex bilaterally (patients), in the left medial frontal gyrus, in the right caudate head and in the right inferior parietal lobule (whole group). No correlations were found in healthy controls. Higher inhibitory right-lateralized alpha power was associated with lower rCBF values in prefrontal and striatal regions, predominantly in the right hemisphere, which are involved in the processing of motivated behavior and reward. Inhibitory brain activity in the reward system may contribute to some of the motivational problems observed in MDD.

Indexed as

RestRewardAdultAgedBrainCerebrovascular CirculationElectroencephalographyFemaleFunctional LateralityHumansImage Processing, Computer-AssistedLinear ModelsMagnetic Resonance ImagingMajor Depressive DisorderMaleMiddle AgedApproach motivationArterial spin labelingEEGFrontal alpha asymmetryMajor depressionReward processing

Identifiers

PMID26590845
OpenAlexW2270870791

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.