ArticleChemistry & biology2015
An L-RNA Aptamer that Binds and Inhibits RNase.
Article in Chemistry & biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 28 citations in OpenAlex.
- Mutagenesis-based evolution enables rapid retargeting of l-aptamers for structured RNA recognition.RSC chemical biology · 2026Article
- A novel L-RNA aptamer to regulate the pUG fold RNA-induced gene expression in vivo.Nucleic acids research · 2025Article
- Targeting PCSK9 as a key player in lipid metabolism: exploiting the therapeutic and biosensing potential of aptamers.Lipids in health and disease · 2024Review
- Synthesis and applications of mirror-image proteins.Nature reviews. Chemistry · 2023Review
- Directed evolution and selection of biostable L-DNA aptamers with a mirror-image DNA polymerase.Nature biotechnology · 2022Article
- Nonbiodegradable Spiegelmer-Driven Colorimetric Biosensor for Bisphenol A Detection.Biosensors · 2022Article
- Advances in TherapeuticGenes · 2021Review
- Circular L-RNA aptamer promotes target recognition and controls gene activity.Nucleic acids research · 2021Article
- Selective aptamer conjugation to silver-coated magnetite nanoparticles for magnetic solid-phase extraction of trace amounts of PbRSC advances · 2021Article
- Specific suppression of D-RNA G-quadruplex-protein interaction with an L-RNA aptamer.Nucleic acids research · 2020Article
- Spiegelmer-Based Sandwich Assay for Cardiac Troponin I Detection.International journal of molecular sciences · 2020Article
- Mirror-Image Oligonucleotides: History and Emerging Applications.Chemistry (Weinheim an der Bergstrasse, Germany) · 2019Review
- Evolution of a General RNA-Cleaving FANA Enzyme.Nature communications · 2018Article
- An Aptamer-Based Probe for Molecular Subtyping of Breast Cancer.Theranostics · 2018Article
- Selection of DNA aptamers with two modified bases.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 2 countries.
Funding
Abstract
L-RNA aptamers were developed that bind to barnase RNase and thereby inhibit the function of the enzyme. These aptamers were obtained by first carrying out in vitro selection of D-RNAs that bind to the full-length synthetic D-enantiomer of barnase, then reversing the mirror and preparing L-RNAs of identical sequence that similarly bind to natural L-barnase. The resulting L-aptamers bind L-barnase with an affinity of ∼100 nM and function as competitive inhibitors of enzyme cleavage of D-RNA substrates. L-RNA aptamers are resistant to degradation by ribonucleases, thus enabling them to function in biological samples, most notably for applications in molecular diagnostics and therapeutics. In addition to the irony of using RNA to inhibit RNase, L-RNA aptamers such as those described here could be used to measure the concentration or inhibit the function of RNase in the laboratory or in biological systems.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.