ArticleCell2015
Calcium and SOL Protease Mediate Temperature Resetting of Circadian Clocks.
Article in Cell, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 16 citations in OpenAlex.
- Soybean Calmodulin-Binding Transcription Activators, GmCAMTA2 and GmCAMTA8, Coordinate the Circadian Regulation of Developmental Processes and Drought Stress Responses.International journal of molecular sciences · 2023Article
- Circadian oscillations of cytosolic free calcium regulate the Arabidopsis circadian clock.Nature plants · 2018Article
- Reconfiguration of a Multi-oscillator Network by Light in the Drosophila Circadian Clock.Current biology : CB · 2018Article
- An N-terminal di-proline motif is essential for fatty acid-dependent degradation of Δ9-desaturase inThe Journal of biological chemistry · 2017Article
- Circadian Rhythms and Sleep inGenetics · 2017Review
- An LHX1-Regulated Transcriptional Network Controls Sleep/Wake Coupling and Thermal Resistance of the Central Circadian Clockworks.Current biology : CB · 2017Article
- miR-124 Regulates the Phase of Drosophila Circadian Locomotor Behavior.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Temperature compensation and temperature sensation in the circadian clock.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- "The Environment is Everything That Isn't Me": Molecular Mechanisms and Evolutionary Dynamics of Insect Clocks in Variable Surroundings.Frontiers in physiology · 2015Review
Corrections and comments
- Retraction · 2017-09-21Falsification/Fabrication of Data · Investigation by Company/Institution · Misconduct - Official Investigation(s) and/or Finding(s) · Misconduct by Author · · Ozgur Tataroglu named as committing misconduct
- Commented on by
- Retracted
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Circadian clocks integrate light and temperature input to remain synchronized with the day/night cycle. Although light input to the clock is well studied, the molecular mechanisms by which circadian clocks respond to temperature remain poorly understood. We found that temperature phase shifts Drosophila circadian clocks through degradation of the pacemaker protein TIM. This degradation is mechanistically distinct from photic CRY-dependent TIM degradation. Thermal TIM degradation is triggered by cytosolic calcium increase and CALMODULIN binding to TIM and is mediated by the atypical calpain protease SOL. This thermal input pathway and CRY-dependent light input thus converge on TIM, providing a molecular mechanism for the integration of circadian light and temperature inputs. Mammals use body temperature cycles to keep peripheral clocks synchronized with their brain pacemaker. Interestingly, downregulating the mammalian SOL homolog SOLH blocks thermal mPER2 degradation and phase shifts. Thus, we propose that circadian thermosensation in insects and mammals share common principles.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.