ArticleNeuron2015
Correspondence between Resting-State Activity and Brain Gene Expression.
Article in Neuron, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
79 citing papers in PubMed, 2 syntheses or guidelines pooled it, 137 citations in OpenAlex.
- Gene co-expression changes underlying the functional connectomic alterations in Alzheimer's disease.BMC medical genomics · 2022Pooled it
- Common neural and transcriptional correlates of inhibitory control underlie emotion regulation and memory control.Social cognitive and affective neuroscience · 2020Pooled it
- Brain circuit-gene expression relationships and neuroplasticity of multisensory cortices in blind children.Proceedings of the National Academy of Sciences of the United States of America · 2017Trial
- Individual-level metabolic connectivity captures cortical morphology and their coupling strengthens in the ageing brain.European journal of nuclear medicine and molecular imaging · 2026Article
- Human cortex organizes dynamic co-fluctuations along the sensorimotor-association axis.Nature communications · 2026Article
- Expression patterns of risk genes associated with three evolutionarily relevant syndromes in rhesus macaque and human brains.Translational psychiatry · 2026Article
- Imaging Genomics Across Primate Species: Advancing Understanding of Neurological and Psychiatric Disorders.Neuroscience bulletin · 2026Review
- Individual-level metabolic connectivity captures cortical morphology and their coupling strengthens with age.bioRxiv : the preprint server for biology · 2026Article
- Neurobiological mechanisms of electroconvulsive therapy in major depressive disorder: structure-function coupling with gene expression and molecular mechanism.Translational psychiatry · 2026Article
- Cortical hierarchy underlying homeostatic sleep pressure alleviation.Nature communications · 2025Article
- Multi-connectomics underpin emotional dysfunction in mouse exposed to simulated space composite environment.Translational psychiatry · 2025Article
- Atypical dynamic neural configuration in autism spectrum disorder and its relationship to gene expression profiles.European child & adolescent psychiatry · 2025Article
- Differences in the amplitude of dynamic low-frequency fluctuations in primary angle-closure glaucoma are associated with gene-molecular multi-omics.Frontiers in medicine · 2025Article
- Human-unique brain cell clusters are associated with learning disorders and human episodic memory activity.Molecular psychiatry · 2025Article
- Extracting interpretable signatures of whole-brain dynamics through systematic comparison.PLoS computational biology · 2024Article
- The genetics of spatiotemporal variation in cortical thickness in youth.Communications biology · 2024Article
- Integration of estimated regional gene expression with neuroimaging and clinical phenotypes at biobank scale.PLoS biology · 2024Article
- Transcriptional expression patterns of the cortical morphometric similarity network in progressive supranuclear palsy.CNS neuroscience & therapeutics · 2024Article
- Extracting interpretable signatures of whole-brain dynamics through systematic comparison.bioRxiv : the preprint server for biology · 2024Article
- Global spatiotemporal synchronizing structures of spontaneous neural activities in different cell types.Nature communications · 2024Article
19 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
The relationship between functional brain activity and gene expression has not been fully explored in the human brain. Here, we identify significant correlations between gene expression in the brain and functional activity by comparing fractional amplitude of low-frequency fluctuations (fALFF) from two independent human fMRI resting-state datasets to regional cortical gene expression from a newly generated RNA-seq dataset and two additional gene expression datasets to obtain robust and reproducible correlations. We find significantly more genes correlated with fALFF than expected by chance and identify specific genes correlated with the imaging signals in multiple expression datasets in the default mode network. Together, these data support a population-level relationship between regional steady-state brain gene expression and resting-state brain activity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.