ArticleApplied and environmental microbiology2016
Determination of Evolutionary Relationships of Outbreak-Associated Listeria monocytogenes Strains of Serotypes 1/2a and 1/2b by Whole-Genome Sequencing.
Article in Applied and environmental microbiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 48 citations in OpenAlex.
- Listeria monocytogenes isolated from a human case of invasive listeriosis survived more than 25 years in a blood culture bottle.Acta veterinaria Scandinavica · 2026Article
- Persistence of microbiological hazards in food and feed production and processing environments.EFSA journal. European Food Safety Authority · 2024Article
- Genome-Wide Association Study ofMicroorganisms · 2022Article
- Genetic Diversity and Relationships ofMicroorganisms · 2022Article
- Phylogenetic and Evolutionary Genomic Analysis ofFrontiers in microbiology · 2022Article
- Genomic Characterization of ClinicalFrontiers in microbiology · 2021Article
- Genomic Determinants of Pathogenicity and Antimicrobial Resistance for 60 GlobalFrontiers in cellular and infection microbiology · 2021Article
- Mutant and Recombinant Phages Selected fromApplied and environmental microbiology · 2020Article
- Dynamics of mobile genetic elements of Listeria monocytogenes persisting in ready-to-eat seafood processing plants in France.BMC genomics · 2020Article
- Genome-Wide Profiling of EnterotoxigenicGenes · 2019Article
- Characterization of the pathogenesis and immune response to Listeria monocytogenes strains isolated from a sustained national outbreak.Scientific reports · 2019Article
- Isolation and identification of Listeria monocytogenes utilizing DC insulator-based dielectrophoresis.Analytica chimica acta · 2019Article
- Looking Backward To Move Forward: the Utility of Sequencing Historical Bacterial Genomes.Journal of clinical microbiology · 2019Review
- Whole-Genome Sequencing and Bioinformatic Analysis of Isolates from Foodborne Illness Outbreaks of Campylobacter jejuni and Salmonella enterica.Journal of clinical microbiology · 2018Article
- Molecular diversity and antimicrobial susceptibility of Listeria monocytogenes isolates from invasive infections in Poland (1997-2013).Scientific reports · 2018Article
- Surviving host - and food relevant stresses: phenotype of L. monocytogenes strains isolated from food and clinical sources.Scientific reports · 2018Article
- Transforming bacterial disease surveillance and investigation using whole-genome sequence to probe the trace.Frontiers of medicine · 2018Review
- Genetic Separation ofFrontiers in cellular and infection microbiology · 2018Article
- Neisseria genomics: current status and future perspectives.Pathogens and disease · 2017Review
- Whole Genome and Core Genome Multilocus Sequence Typing and Single Nucleotide Polymorphism Analyses of Listeria monocytogenes Isolates Associated with an Outbreak Linked to Cheese, United States, 2013.Applied and environmental microbiology · 2017Article
Corrections and comments
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Authors and funding
15 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We used whole-genome sequencing to determine evolutionary relationships among 20 outbreak-associated clinical isolates of Listeria monocytogenes serotypes 1/2a and 1/2b. Isolates from 6 of 11 outbreaks fell outside the clonal groups or "epidemic clones" that have been previously associated with outbreaks, suggesting that epidemic potential may be widespread in L. monocytogenes and is not limited to the recognized epidemic clones. Pairwise comparisons between epidemiologically related isolates within clonal complexes showed that genome-level variation differed by 2 orders of magnitude between different comparisons, and the distribution of point mutations (core versus accessory genome) also varied. In addition, genetic divergence between one closely related pair of isolates from a single outbreak was driven primarily by changes in phage regions. The evolutionary analysis showed that the changes could be attributed to horizontal gene transfer; members of the diverse bacterial community found in the production facility could have served as the source of novel genetic material at some point in the production chain. The results raise the question of how to best utilize information contained within the accessory genome in outbreak investigations. The full magnitude and complexity of genetic changes revealed by genome sequencing could not be discerned from traditional subtyping methods, and the results demonstrate the challenges of interpreting genetic variation among isolates recovered from a single outbreak. Epidemiological information remains critical for proper interpretation of nucleotide and structural diversity among isolates recovered during outbreaks and will remain so until we understand more about how various population histories influence genetic variation.
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