ArticleNucleic acids research2016
MutationAligner: a resource of recurrent mutation hotspots in protein domains in cancer.
Article in Nucleic acids research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Convergent Evolution in Tumor Genomes Targets Functional Domains.bioRxiv : the preprint server for biology · 2026Article
- MutationAssessor in cBioPortal.bioRxiv : the preprint server for biology · 2025Article
- Mapping structural distribution and gating-property impacts of disease-associated mutations in voltage-gated sodium channels.iScience · 2024Article
- Genome-scale exon perturbation screens uncover exons critical for cell fitness.Molecular cell · 2024Article
- Review
- Singleton mutations in large-scale cancer genome studies: uncovering the tail of cancer genome.NAR cancer · 2024Article
- Integrating Clinical Cancer and PTM Proteomics Data Identifies a Mechanism of ACK1 Kinase Activation.Molecular cancer research : MCR · 2024Article
- Tailoring Multi-omics to Inflammatory Bowel Diseases: All for One and One for All.Journal of Crohn's & colitis · 2022Article
- Mutation in Abl kinase with altered drug-binding kinetics indicates a novel mechanism of imatinib resistance.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Article
- PJAMIA open · 2021Article
- Protein interaction disruption in cancer.BMC cancer · 2019Article
- A CATH domain functional family based approach to identify putative cancer driver genes and driver mutations.Scientific reports · 2019Article
- Integration of Random Forest Classifiers and Deep Convolutional Neural Networks for Classification and Biomolecular Modeling of Cancer Driver Mutations.Frontiers in molecular biosciences · 2019Article
- Identification and analysis of mutational hotspots in oncogenes and tumour suppressors.Oncotarget · 2017Article
- Distribution bias analysis of germline and somatic single-nucleotide variations that impact protein functional site and neighboring amino acids.Scientific reports · 2017Article
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Authors and funding
7 authors.
Funding
Abstract
The MutationAligner web resource, available at http://www.mutationaligner.org, enables discovery and exploration of somatic mutation hotspots identified in protein domains in currently (mid-2015) more than 5000 cancer patient samples across 22 different tumor types. Using multiple sequence alignments of protein domains in the human genome, we extend the principle of recurrence analysis by aggregating mutations in homologous positions across sets of paralogous genes. Protein domain analysis enhances the statistical power to detect cancer-relevant mutations and links mutations to the specific biological functions encoded in domains. We illustrate how the MutationAligner database and interactive web tool can be used to explore, visualize and analyze mutation hotspots in protein domains across genes and tumor types. We believe that MutationAligner will be an important resource for the cancer research community by providing detailed clues for the functional importance of particular mutations, as well as for the design of functional genomics experiments and for decision support in precision medicine. MutationAligner is slated to be periodically updated to incorporate additional analyses and new data from cancer genomics projects.
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