Evidence map›Paper›PMID 26590263›Full record

ArticleNucleic acids research2016

Lynx: a knowledge base and an analytical workbench for integrative medicine.

Dinanath Sulakhe, Bingqing Xie, Andrew Taylor, Mark D'Souza, Sandhya Balasubramanian, Somaye Hashemifar, Steven White, Utpal J Dave, Gady Agam, Jinbo Xu and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nucleic acids research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Dinanath SulakheDepartment of Human Genetics, University of Chicago, 920 E. 58th Street, Chicago, IL 60637, USA Computation Institute, University of Chicago, 5735 S. Ellis Avenue, Chicago, IL 60637, USA sulakhe@uchicago.edu.
Bingqing XieDepartment of Human Genetics, University of Chicago, 920 E. 58th Street, Chicago, IL 60637, USA Department of Computer Science, Illinois Institute of Technology, Chicago, IL 60616, USA.
Andrew TaylorDepartment of Human Genetics, University of Chicago, 920 E. 58th Street, Chicago, IL 60637, USA.
Mark D'SouzaDepartment of Human Genetics, University of Chicago, 920 E. 58th Street, Chicago, IL 60637, USA.
Sandhya BalasubramanianDepartment of Human Genetics, University of Chicago, 920 E. 58th Street, Chicago, IL 60637, USA.
Somaye HashemifarToyota Technological Institute at Chicago, 6045 S. Kenwood Avenue, Chicago, IL 60637, USA.
Steven WhiteDepartment of Medicine, University of Chicago, 5841 S. Maryland Avenue, Chicago, IL 60637, USA.
Utpal J DaveComputation Institute, University of Chicago, 5735 S. Ellis Avenue, Chicago, IL 60637, USA.
Gady AgamDepartment of Computer Science, Illinois Institute of Technology, Chicago, IL 60616, USA.
Jinbo XuToyota Technological Institute at Chicago, 6045 S. Kenwood Avenue, Chicago, IL 60637, USA.
Sheng WangDepartment of Human Genetics, University of Chicago, 920 E. 58th Street, Chicago, IL 60637, USA Toyota Technological Institute at Chicago, 6045 S. Kenwood Avenue, Chicago, IL 60637, USA.
T Conrad GilliamDepartment of Human Genetics, University of Chicago, 920 E. 58th Street, Chicago, IL 60637, USA Computation Institute, University of Chicago, 5735 S. Ellis Avenue, Chicago, IL 60637, USA.
Natalia MaltsevDepartment of Human Genetics, University of Chicago, 920 E. 58th Street, Chicago, IL 60637, USA Computation Institute, University of Chicago, 5735 S. Ellis Avenue, Chicago, IL 60637, USA maltsev@uchicago.edu.

Funding

Re-Engineering Translational Research at the University of ChicagoUL1TR000430 · NCATS · UNIVERSITY OF CHICAGO · PI SOLWAY, JULIAN · 2012 to 2016
$20.2M
The Genetic Basis of Mid-Hindbrain MalformationsR01NS050375 · NINDS · UNIVERSITY OF MINNESOTA · PI DOBYNS, WILLIAM B. · 2005 to 2019
$9.9M
Center for Genomic and Phenomic Studies in AutismU24MH081810 · NIMH · UNIVERSITY OF SOUTHERN CALIFORNIA · PI LAJONCHERE, CLARA M · 2007 to 2011
$8.3M
New Computational Methods for Data-driven Protein Structure PredictionR01GM089753 · NIGMS · TOYOTA TECHNOLOGICAL INSTITUTE / CHICAGO · PI XU, JINBO · 2010 to 2023
$3.8M
NCATS NIH HHS UL1 TR000430NIGMS NIH HHS R01 GM089753NIMH NIH HHS 1U24MH081810NINDS NIH HHS NS050375
6 · The paper itself

Abstract

Lynx (http://lynx.ci.uchicago.edu) is a web-based database and a knowledge extraction engine. It supports annotation and analysis of high-throughput experimental data and generation of weighted hypotheses regarding genes and molecular mechanisms contributing to human phenotypes or conditions of interest. Since the last release, the Lynx knowledge base (LynxKB) has been periodically updated with the latest versions of the existing databases and supplemented with additional information from public databases. These additions have enriched the data annotations provided by Lynx and improved the performance of Lynx analytical tools. Moreover, the Lynx analytical workbench has been supplemented with new tools for reconstruction of co-expression networks and feature-and-network-based prioritization of genetic factors and molecular mechanisms. These developments facilitate the extraction of meaningful knowledge from experimental data and LynxKB. The Service Oriented Architecture provides public access to LynxKB and its analytical tools via user-friendly web services and interfaces.

Indexed as

Databases, GeneticIntegrative MedicineKnowledge BasesData MiningGene Regulatory NetworksGenesHumansMolecular Sequence AnnotationPhenotype

Identifiers

PMID26590263
PMCPMC4702889

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.