Evidence map›Paper›PMID 26590260›Full record

ArticleNucleic acids research2016

miRTarBase 2016: updates to the experimentally validated miRNA-target interactions database.

Chih-Hung Chou, Nai-Wen Chang, Sirjana Shrestha, Sheng-Da Hsu, Yu-Ling Lin, Wei-Hsiang Lee, Chi-Dung Yang, Hsiao-Chin Hong, Ting-Yen Wei, Siang-Jyun Tu and 17 more

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In one paragraph

Article in Nucleic acids research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 606 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
606citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

606 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
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  17. MicroRNA Profiling in Non-model Plants Using Microarray Hybridization.Methods in molecular biology (Clifton, N.J.) · 2025
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546 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Chih-Hung ChouInstitute of Bioinformatics and Systems Biology, National Chiao Tung University, Hsinchu, 300, Taiwan.
Nai-Wen ChangGraduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, 106, Taiwan.
Sirjana ShresthaDepartment of Biological Science and Technology, National Chiao Tung University, Hsinchu, 300, Taiwan.
Sheng-Da HsuInstitute of Bioinformatics and Systems Biology, National Chiao Tung University, Hsinchu, 300, Taiwan.
Yu-Ling LinDepartment of Biological Science and Technology, National Chiao Tung University, Hsinchu, 300, Taiwan Center for Bioinformatics Research, National Chiao Tung University, Hsinchu, 300, Taiwan.
Wei-Hsiang LeeInstitute of Bioinformatics and Systems Biology, National Chiao Tung University, Hsinchu, 300, Taiwan Clinical Research Center, Chung Shan Medical University Hospital, Taichung, 402, Taiwan.
Chi-Dung YangInstitute of Bioinformatics and Systems Biology, National Chiao Tung University, Hsinchu, 300, Taiwan Institute of Population Health Sciences, National Health Research Institutes, Miaoli, 350, Taiwan.
Hsiao-Chin HongInstitute of Bioinformatics and Systems Biology, National Chiao Tung University, Hsinchu, 300, Taiwan.
Ting-Yen WeiInterdisciplinary Program of Life Science, National Tsing Hua University, Hsinchu, 300, Taiwan.
Siang-Jyun TuDepartment of Biological Science and Technology, National Chiao Tung University, Hsinchu, 300, Taiwan.
Tzi-Ren TsaiDepartment of Biological Science and Technology, National Chiao Tung University, Hsinchu, 300, Taiwan.
Shu-Yi HoDepartment of Biological Science and Technology, National Chiao Tung University, Hsinchu, 300, Taiwan.
Ting-Yan JianInstitute of Molecular Medicine and Bioengineering, National Chiao Tung University, Hsinchu, 300, Taiwan.
Hsin-Yi WuInstitute of Molecular Medicine and Bioengineering, National Chiao Tung University, Hsinchu, 300, Taiwan.
Pin-Rong ChenInstitute of Molecular Medicine and Bioengineering, National Chiao Tung University, Hsinchu, 300, Taiwan.
Nai-Chieh LinInstitute of Bioinformatics and Systems Biology, National Chiao Tung University, Hsinchu, 300, Taiwan.
Hsin-Tzu HuangDegree Program of Applied Science and Technology, National Chiao Tung University, Hsinchu, 300, Taiwan.
Tzu-Ling YangInstitute of Bioinformatics and Systems Biology, National Chiao Tung University, Hsinchu, 300, Taiwan.
Chung-Yuan PaiInstitute of Molecular Medicine and Bioengineering, National Chiao Tung University, Hsinchu, 300, Taiwan.
Chun-San TaiInstitute of Bioinformatics and Systems Biology, National Chiao Tung University, Hsinchu, 300, Taiwan Institute of Molecular Medicine and Bioengineering, National Chiao Tung University, Hsinchu, 300, Taiwan.
Wen-Liang ChenInstitute of Bioinformatics and Systems Biology, National Chiao Tung University, Hsinchu, 300, Taiwan Department of Biological Science and Technology, National Chiao Tung University, Hsinchu, 300, Taiwan.
Chia-Yen HuangDepartment of Biological Science and Technology, National Chiao Tung University, Hsinchu, 300, Taiwan Gynecologic Cancer Center, Department of Obstetrics and Gynecology, Cathay General Hospital, Taipei, 106, Taiwan.
Chun-Chi LiuInstitute of Genomics and Bioinformatics, National Chung Hsing University, Taichung, 402, Taiwan.
Shun-Long WengDepartment of Obstetrics and Gynecology, Hsinchu Mackay Memorial Hospital, Hsinchu, 300, Taiwan Mackay Medicine, Nursing and Management College, Taipei, 112, Taiwan Department of Medicine, Mackay Medical College, New Taipei City, 252, Taiwan.
Kuang-Wen LiaoDepartment of Biological Science and Technology, National Chiao Tung University, Hsinchu, 300, Taiwan Institute of Molecular Medicine and Bioengineering, National Chiao Tung University, Hsinchu, 300, Taiwan.
Wen-Lian HsuInstitute of Information Science, Academia Sinica, Taipei, 115, Taiwan hsu@iis.sinica.edu.tw.
Hsien-Da HuangInstitute of Bioinformatics and Systems Biology, National Chiao Tung University, Hsinchu, 300, Taiwan Department of Biological Science and Technology, National Chiao Tung University, Hsinchu, 300, Taiwan Center for Bioinformatics Research, National Chiao Tung University, Hsinchu, 300, Taiwan Department of Biomedical Science and Environmental Biology, Kaohsiung Medical University, Kaohsiung, 807, Taiwan bryan@mail.nctu.edu.tw.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

MicroRNAs (miRNAs) are small non-coding RNAs of approximately 22 nucleotides, which negatively regulate the gene expression at the post-transcriptional level. This study describes an update of the miRTarBase (http://miRTarBase.mbc.nctu.edu.tw/) that provides information about experimentally validated miRNA-target interactions (MTIs). The latest update of the miRTarBase expanded it to identify systematically Argonaute-miRNA-RNA interactions from 138 crosslinking and immunoprecipitation sequencing (CLIP-seq) data sets that were generated by 21 independent studies. The database contains 4966 articles, 7439 strongly validated MTIs (using reporter assays or western blots) and 348 007 MTIs from CLIP-seq. The number of MTIs in the miRTarBase has increased around 7-fold since the 2014 miRTarBase update. The miRNA and gene expression profiles from The Cancer Genome Atlas (TCGA) are integrated to provide an effective overview of this exponential growth in the miRNA experimental data. These improvements make the miRTarBase one of the more comprehensively annotated, experimentally validated miRNA-target interactions databases and motivate additional miRNA research efforts.

Indexed as

Databases, Nucleic AcidDiseaseGene Expression ProfilingHumansMicroRNAsRNA, MessengerSequence Analysis, RNAMicroRNAsRNA, Messenger

Identifiers

PMID26590260
PMCPMC4702890

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.