ArticleJournal of Crohn's & colitis2016
Diagnostic Delay in Romanian Patients with Inflammatory Bowel Disease: Risk Factors and Impact on the Disease Course and Need for Surgery.
Article in Journal of Crohn's & colitis, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 2 of them syntheses that pooled it.
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Who cites it
39 citing papers in PubMed, 2 syntheses or guidelines pooled it, 82 citations in OpenAlex.
- Early diagnosis of Crohn's disease in patients presenting with a perianal fistula: systematic review and development of a perianal red flags index.Techniques in coloproctology · 2025Pooled it
- Diagnostic Delay in Pediatric Inflammatory Bowel Disease: A Systematic Review.Digestive diseases and sciences · 2022Pooled it
- Impact of Delayed Diagnosis in IBD on Clinical Outcomes and Healthcare Delivery.Diagnostics (Basel, Switzerland) · 2026Article
- Possible underdiagnosis of ulcerative colitis in tertiary care can affect medication use and access to healthcare facilities.Frontiers in immunology · 2026Article
- Prevalence, associated factors, and nomogram model of suicidality among incarcerated individuals: a developmental adaptation perspective for targeted prevention strategies.BMC psychiatry · 2025Article
- Prolonged Time to Diagnosis of Crohn's Disease in Patients With Perianal Fistulas Negatively Affects Long-Term Outcomes.Journal of Crohn's & colitis · 2025Article
- Artificial Intelligence as a Tool in Diagnosing Inflammatory Bowel Disease in Older Adults.Journal of clinical medicine · 2025Article
- Patient and physician factors contributing to delays in inflammatory bowel diseases: Enhancing timely diagnosis.World journal of gastroenterology · 2025Article
- Reactions, Reality, and Resilience in Adults with Crohn's Disease: A Qualitative Study.Crohn's & colitis 360 · 2025Article
- Diagnostic delay in inflammatory bowel diseases in a German population.World journal of gastroenterology · 2024Article
- Postoperative outcomes of surgical delay in inflammatory bowel disease patients: a multicenter cohort study.Updates in surgery · 2024Article
- Global geoepidemiology of gastrointestinal surgery rates in Crohn's disease.World journal of gastrointestinal surgery · 2024Article
- Associations between prior healthcare use, time to diagnosis, and clinical outcomes in inflammatory bowel disease: a nationally representative population-based cohort study.BMJ open gastroenterology · 2024Article
- Supervised Machine Learning Classifies Inflammatory Bowel Disease Patients by Subtype Using Whole Exome Sequencing Data.Journal of Crohn's & colitis · 2023Article
- Questionnaire Survey for Inflammatory Bowel Disease Patients in Japan; A Web-Based Japan, Crohn's Disease, Ulcerative Colitis, Patients Survey.Crohn's & colitis 360 · 2023Article
- Factors associated with delayed diagnosis of Crohn's disease: A systematic review and meta-analysis.Heliyon · 2023Article
- Surgery for Inflammatory Bowel Disease in the Era of Biologic Therapy: A Multicenter Experience from Romania.Medicina (Kaunas, Lithuania) · 2023Article
- Diagnostic Delay in Paediatric Inflammatory Bowel Disease-A Systematic Investigation.Journal of clinical medicine · 2022Article
- Impact of Diagnostic Delay on Disease Course in Pediatric- versus Adult-Onset Patients with Ulcerative Colitis: Data from the Swiss IBD Cohort.Inflammatory intestinal diseases · 2022Article
- Diagnostic Delay of Inflammatory Bowel Disease Is Significantly Higher in Public versus Private Health Care System in Mexican Patients.Inflammatory intestinal diseases · 2022Article
Corrections and comments
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Authors and funding
15 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe epidemiology of inflammatory bowel disease [IBD] in Eastern Europe is poorly understood, particularly with regard to diagnostic delay. Here we investigated the factors leading to delayed diagnosis and the effect of the delay on several disease progression and outcome measures.
methodsA total of 1196 IBD cases [682 ulcerative colitis [UC], 478 Crohn's disease [CD], 36 indeterminate colitis] from the Romanian national registry IBDPROSPECT were reviewed. Standard clinical and demographic factors were evaluated as predictors of a long diagnostic delay in both CD and UC. Diagnostic delay was subsequently evaluated as a potential risk factor for bowel stenoses, bowel fistulas, perianal fistulas, perianal surgery, and intestinal surgery in CD patients.
resultsThe median diagnostic delay was significantly longer in CD [5 months] than in UC [1 month] patients [p < 0.001]. Compared with 5 months for UC patients, 75% of CD patients were diagnosed within 18 months of symptom onset. In CD patients, extra-ileal location was a protective factor (odds ratio [OR], 0.5; p = 0.03), whereas being an active smoker [OR, 2.09; p = 0.01] and symptom onset during summer [OR, 3.35; p < 0.001] were independent risk factors for a long diagnostic delay [> 18 months]. In UC patients, an age > 40 years was a protective factor [OR, 0.68; p = 0.04] for a long delay. Regarding outcomes, a long diagnostic delay in CD patients positively correlated with bowel stenoses [OR, 3.38; p < 0.01] and any IBD-related surgery [OR, 1.95; p = 0.03] and had a positive trend for intestinal fistulas [OR, 2.64; p = 0.08] and perianal fistulas [OR, 2.9; p = 0.07]. Disease duration since diagnosis positively correlated with bowel stenoses [OR, 1.04; p = 0.04], any IBD-related surgery [OR, 1.04; p = 0.02], and intestinal surgery [OR, 1.07; p < 0.01].
conclusionsA long diagnostic delay in IBD correlates with an increased frequency of bowel stenoses and need for IBD-related surgery.
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