Evidence map›Paper›PMID 26589938›Full record

ReviewCurrent topics in developmental biology2015

Morphometrics, 3D Imaging, and Craniofacial Development.

Benedikt Hallgrimsson, Christopher J Percival, Rebecca Green, Nathan M Young, Washington Mio, Ralph Marcucio

Abstract readReview
In one paragraph

Review in Current topics in developmental biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Habitat-Driven Sexual Dimorphism inEcology and evolution · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Benedikt HallgrimssonDepartment of Cell Biology and Anatomy, Alberta Children's Hospital Research Institute, and McCaig Bone and Joint Institute, University of Calgary, Calgary, Alberta, Canada. Electronic address: bhallgri@ucalgary.ca.
Christopher J PercivalDepartment of Cell Biology and Anatomy, Alberta Children's Hospital Research Institute, and McCaig Bone and Joint Institute, University of Calgary, Calgary, Alberta, Canada.
Rebecca GreenDepartment of Cell Biology and Anatomy, Alberta Children's Hospital Research Institute, and McCaig Bone and Joint Institute, University of Calgary, Calgary, Alberta, Canada.
Nathan M YoungDepartment of Orthopaedic Surgery, San Francisco General Hospital, Orthopaedic Trauma Institute, University of California San Francisco, San Francisco, California, USA.
Washington MioDepartment of Mathematics, Florida State University, Tallahassee, Florida, USA.
Ralph MarcucioDepartment of Orthopaedic Surgery, San Francisco General Hospital, Orthopaedic Trauma Institute, University of California San Francisco, San Francisco, California, USA.

Funding

The role of continuous phenotypic variation in structural defects of the faceR01DE019638 · NIDCR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Benedikt Hallgrimsson, Ralph S Marcucio · 2010 to 2026
$7.3M
Developing 3D Craniofacial Morphometry Data and Tools to Transform DysmorphologyU01DE024440 · NIDCR · UNIVERSITY OF COLORADO DENVER · PI HALLGRIMSSON, BENEDIKT, KLEIN, OPHIR D · 2014 to 2018
$3.3M
Genetic Determinants of Orofacial Shape and Relationship to Cleft Lip/PalateU01DE020054 · NIDCR · UNIVERSITY OF COLORADO DENVER · PI SPRITZ, RICHARD ANDREW · 2009 to 2014
$2.4M
Developmental mechanisms underlying genotype-phenotype correlationsR01DE021708 · NIDCR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HALLGRIMSSON, BENEDIKT, MARCUCIO, RALPH S · 2011 to 2015
$1.9M
NIDCR NIH HHS 1R01DE021708NIDCR NIH HHS 1U01DE024440NIDCR NIH HHS R01 DE019638NIDCR NIH HHS R01 DE021708NIDCR NIH HHS U01 DE020054NIDCR NIH HHS U01 DE024440
6 · The paper itself

Abstract

Recent studies have shown how volumetric imaging and morphometrics can add significantly to our understanding of morphogenesis, the developmental basis for variation, and the etiology of structural birth defects. On the other hand, the complex questions and diverse imaging data in developmental biology present morphometrics with more complex challenges than applications in virtually any other field. Meeting these challenges is necessary in order to understand the mechanistic basis for variation in complex morphologies. This chapter reviews the methods and theory that enable the application of modern landmark-based morphometrics to developmental biology and craniofacial development, in particular. We discuss the theoretical foundations of morphometrics as applied to development and review the basic approaches to the quantification of morphology. Focusing on geometric morphometrics, we discuss the principal statistical methods for quantifying and comparing morphological variation and covariation structure within and among groups. Finally, we discuss the future directions for morphometrics in developmental biology that will be required for approaches that enable quantitative integration across the genotype-phenotype map.

Indexed as

MorphogenesisAnatomy, ComparativeAnimalsBone and BonesCraniofacial AbnormalitiesHumansImaging, Three-DimensionalMiceReproducibility of ResultsSensitivity and SpecificityCraniofacialImagingMicroCTMorphogenesisMorphometricsMouseOptical Projection TomographyPhenomics

Identifiers

PMID26589938
PMCPMC5299999

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.