Evidence map›Paper›PMID 26589935›Full record

ReviewCurrent topics in developmental biology2015

From Bench to Bedside and Back: Improving Diagnosis and Treatment of Craniofacial Malformations Utilizing Animal Models.

Alice F Goodwin, Rebecca Kim, Jeffrey O Bush, Ophir D Klein

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current topics in developmental biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
5.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Normscan: open-source Python software to create average models from CT scans.International journal of computer assisted radiology and surgery · 2025
    Article
  4. AnDevelopment (Cambridge, England) · 2020
    Article
  5. What Do Animal Models Teach Us About Congenital Craniofacial Defects?Advances in experimental medicine and biology · 2020
    Review
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Alice F GoodwinProgram in Craniofacial Biology, University of California San Francisco, San Francisco, California, USA; Department of Orofacial Sciences, University of California San Francisco, San Francisco, California, USA.
Rebecca KimProgram in Craniofacial Biology, University of California San Francisco, San Francisco, California, USA; Department of Orofacial Sciences, University of California San Francisco, San Francisco, California, USA.
Jeffrey O BushProgram in Craniofacial Biology, University of California San Francisco, San Francisco, California, USA; Department of Cell and Tissue Biology, University of California San Francisco, San Francisco, California, USA; Institute for Human Genetics, University of California San Francisco, San Francisco, California, USA. Electronic address: jeffrey.bush@ucsf.edu.
Ophir D KleinProgram in Craniofacial Biology, University of California San Francisco, San Francisco, California, USA; Department of Orofacial Sciences, University of California San Francisco, San Francisco, California, USA; Department of Pediatrics, University of California San Francisco, San Francisco, California, USA; Institute for Human Genetics, University of California San Francisco, San Francisco, California, USA. Electronic address: ophir.klein@ucsf.edu.
University of California, San Francisco · US

Funding

Mechanisms of Eph/Ephrin signaling in craniofacial morphogenesis and craniofrontonasal syndromeR01DE023337 · NIDCR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BUSH, JEFFREY OHMANN · 2013 to 2021
$4.3M
Developing 3D Craniofacial Morphometry Data and Tools to Transform DysmorphologyU01DE024440 · NIDCR · UNIVERSITY OF COLORADO DENVER · PI HALLGRIMSSON, BENEDIKT, KLEIN, OPHIR D · 2014 to 2018
$3.3M
UCSF Core Center for Musculoskeletal Biology and MedicineP30AR066262 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MAJUMDAR, SHARMILA · 2014 to 2018
$3.0M
The role of Bmi1 in regulation of dental stem cellsR01DE021420 · NIDCR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KLEIN, OPHIR D · 2011 to 2015
$2.0M
The Role of Wnt Signaling in Early Tooth DevelopmentF30DE025160 · NIDCR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KIM, REBECCA · 2015 to 2021
$323k
Analysis of the Role of Ras Signaling in AmelogenesisF30DE022205 · NIDCR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GOODWIN, ALICE FITZGERALD · 2011 to 2012
$75k
NIAMS NIH HHS P30 AR066262NIDCR NIH HHS F30 DE022205NIDCR NIH HHS F30 DE025160NIDCR NIH HHS F30-DE025160NIDCR NIH HHS R01 DE021420NIDCR NIH HHS R01-DE021420NIDCR NIH HHS R01 DE023337NIDCR NIH HHS R01-DE023337NIDCR NIH HHS U01 DE024440NIDCR NIH HHS U01-DE024440
6 · The paper itself

Abstract

Craniofacial anomalies are among the most common birth defects and are associated with increased mortality and, in many cases, the need for lifelong treatment. Over the past few decades, dramatic advances in the surgical and medical care of these patients have led to marked improvements in patient outcomes. However, none of the treatments currently in clinical use address the underlying molecular causes of these disorders. Fortunately, the field of craniofacial developmental biology provides a strong foundation for improved diagnosis and for therapies that target the genetic causes of birth defects. In this chapter, we discuss recent advances in our understanding of the embryology of craniofacial conditions, and we focus on the use of animal models to guide rational therapies anchored in genetics and biochemistry.

Indexed as

Disease Models, AnimalAnimalsCraniofacial AbnormalitiesGene Expression Regulation, DevelopmentalGenetic Predisposition to DiseaseHumansModels, GeneticMutationSignal TransductionTranslational Research, BiomedicalCleft lip and palateCraniofacial anomaliesCraniosynostosisDevelopmental biologyEctodermal dysplasiaRASopathiesTreacher CollinsXLHED

Identifiers

PMID26589935
PMCPMC7398124
OpenAlexW1846970467

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.