Evidence map›Paper›PMID 26589928›Full record

ReviewCurrent topics in developmental biology2015

Zebrafish Craniofacial Development: A Window into Early Patterning.

Lindsey Mork, Gage Crump

Open access · greenAbstract readReview
In one paragraph

Review in Current topics in developmental biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 102 papers.

0numbers the graph read from it
0cells of the map it votes in
102citing papers in PubMed
11.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

102 citing papers in PubMed, 185 citations in OpenAlex.

  1. Article
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  10. foxe1 mutant zebrafish show indications of a hypothyroid phenotype and increased sensitivity to ethanol for craniofacial malformations.Developmental dynamics : an official publication of the American Association of Anatomists · 2025
    Article
  11. Article
  12. A potential role of Fgf3 for epibranchial formation in zebrafish.Frontiers in cell and developmental biology · 2025
    Article
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  15. Genetic requirement ofbioRxiv : the preprint server for biology · 2024
    Article
  16. Article
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  19. Review
  20. Article

42 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Lindsey MorkEli and Edythe Broad CIRM Center for Regenerative Medicine and Stem Cell Research at the University of Southern California, Los Angeles, California, USA.
Gage CrumpEli and Edythe Broad CIRM Center for Regenerative Medicine and Stem Cell Research at the University of Southern California, Los Angeles, California, USA. Electronic address: gcrump@usc.edu.
Broad Center · US

Funding

Training in Hearing & Communication NeuroscienceT32DC009975 · NIDCD · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Christopher A Shera · 2009 to 2026
$5.0M
Epithelial-mesenchymal interactions in facial patterningR01DE018405 · NIDCR · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CRUMP, GAGE D · 2007 to 2017
$4.1M
NIDCD NIH HHS T32 DC009975NIDCR NIH HHS R01 DE018405
6 · The paper itself

Abstract

The formation of the face and skull involves a complex series of developmental events mediated by cells derived from the neural crest, endoderm, mesoderm, and ectoderm. Although vertebrates boast an enormous diversity of adult facial morphologies, the fundamental signaling pathways and cellular events that sculpt the nascent craniofacial skeleton in the embryo have proven to be highly conserved from fish to man. The zebrafish Danio rerio, a small freshwater cyprinid fish from eastern India, has served as a popular model of craniofacial development since the 1990s. Unique strengths of the zebrafish model include a simplified skeleton during larval stages, access to rapidly developing embryos for live imaging, and amenability to transgenesis and complex genetics. In this chapter, we describe the anatomy of the zebrafish craniofacial skeleton; its applications as models for the mammalian jaw, middle ear, palate, and cranial sutures; the superior imaging technology available in fish that has provided unprecedented insights into the dynamics of facial morphogenesis; the use of the zebrafish to decipher the genetic underpinnings of craniofacial biology; and finally a glimpse into the most promising future applications of zebrafish craniofacial research.

Indexed as

Body PatterningAnimalsCraniofacial AbnormalitiesDisease Models, AnimalEmbryo, NonmammalianHumansLarvaSignal TransductionSkullZebrafishComplex geneticsCraniofacialSkeletal regenerationTime-lapse imagingVertebrate evolutionZebrafish

Identifiers

PMID26589928
PMCPMC4758817
OpenAlexW2141363043

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.