Evidence map›Paper›PMID 26589923›Full record

ReviewCurrent topics in developmental biology2015

Regulatory Mechanisms Driving Salivary Gland Organogenesis.

Belinda R Hauser, Matthew P Hoffman

Open access · greenAbstract readReview
In one paragraph

Review in Current topics in developmental biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
10.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 36 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Thymus Ontogeny and Development.Advances in experimental medicine and biology · 2025
    Review
  5. Article
  6. Review
  7. Article
  8. Review
  9. Review
  10. Cell signaling regulation in salivary gland development.Cellular and molecular life sciences : CMLS · 2021
    Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Molecular Regulatory Mechanism of Exocytosis in the Salivary Glands.International journal of molecular sciences · 2018
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Belinda R HauserMatrix and Morphogenesis Section, Laboratory of Cell and Developmental Biology, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA.
Matthew P HoffmanMatrix and Morphogenesis Section, Laboratory of Cell and Developmental Biology, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA. Electronic address: mhoffman@mail.nih.gov.
National Institutes of Health · US

Funding

Growth Factor/Extracellular Matrix Interactions During Branching MorphogenesisZIADE000707 · NIDCR · NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH · PI HOFFMAN, MATTHEW · 2009 to 2023
$14.0M
Progenitor/Stem Cell Function During Salivary Gland DevelopmentZIADE000722 · NIDCR · NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH · PI HOFFMAN, MATTHEW · 2009 to 2023
$13.7M
Growth Factor/Extracellular Matrix Interactions During Branching MorphogenesisZ01DE000707 · NIDCR · NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH · PI HOFFMAN, MATTHEW P · 2004 to 2008
$1.8M
Neuronal and Progenitor/Stem Cell Function During Salivary Gland DevelopmentZ01DE000722 · NIDCR · NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH · PI HOFFMAN, MATTHEW · 2008 to 2008
$528k
Intramural NIH HHS Z01 DE000707Intramural NIH HHS Z01 DE000722
6 · The paper itself

Abstract

Salivary glands develop as highly branched structures designed to produce and secrete saliva. Advances in mouse genetics, stem cell biology, and regenerative medicine are having a tremendous impact on our understanding of salivary gland organogenesis. Understanding how submandibular gland (SMG) initiation, branching morphogenesis, and cell differentiation occur, as well as defining the progenitor/stem cells and cell and tissue interactions that drive SMG development will help guide regenerative approaches for patients suffering from loss of salivary gland function. This review focuses on recent literature from the past 5 years investigating the regulatory mechanisms driving SMG organogenesis.

Indexed as

OrganogenesisAnimalsCell DifferentiationEpitheliumFibroblast Growth Factor 10Gene Expression Regulation, DevelopmentalHumansSalivary GlandsStem CellsSubmandibular GlandFibroblast Growth Factor 10Branching morphogenesisDevelopmentDifferentiationMicroenvironmentMicroRNAsOrganogenesisProgenitor cellsSalivary glandSalivary stem cellStem cell niche

Identifiers

PMID26589923
PMCPMC5545788
OpenAlexW2394994569

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.