Evidence map›Paper›PMID 26589910›Full record

ArticleHaematologica2016

Expression and function of ABC-transporter protein ABCB1 correlates with inhibitory capacity of Ruxolitinib in vitro and in vivo.

Caroline Ebert, Florian Perner, Denise Wolleschak, Tina M Schnöder, Thomas Fischer, Florian H Heidel

Open access · goldAbstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in Haematologica, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Expression ofMedicina (Kaunas, Lithuania) · 2023
    Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Caroline EbertDepartment of Hematology and Oncology, Center of Internal Medicine, Otto-von-Guericke University Medical Center, Magdeburg.
Florian PernerDepartment of Hematology and Oncology, Center of Internal Medicine, Otto-von-Guericke University Medical Center, Magdeburg.
Denise WolleschakDepartment of Hematology and Oncology, Center of Internal Medicine, Otto-von-Guericke University Medical Center, Magdeburg.
Tina M SchnöderDepartment of Hematology and Oncology, Center of Internal Medicine, Otto-von-Guericke University Medical Center, Magdeburg Collaborative Research Cluster 854, Medical Faculty, Otto-von-Guericke University Medical Center, Magdeburg.
Thomas FischerDepartment of Hematology and Oncology, Center of Internal Medicine, Otto-von-Guericke University Medical Center, Magdeburg Collaborative Research Cluster 854, Medical Faculty, Otto-von-Guericke University Medical Center, Magdeburg.
Florian H HeidelDepartment of Hematology and Oncology, Center of Internal Medicine, Otto-von-Guericke University Medical Center, Magdeburg Collaborative Research Cluster 854, Medical Faculty, Otto-von-Guericke University Medical Center, Magdeburg Internal Medicine II, Department of Hematology and Oncology, Friedrich-Schiller-University Jena Current Address: Leibniz-Institute on Aging, Fritz-Lipmann-Institute, Jena, Germany florian.h.heidel@gmail.com.
University Medical Center · USOtto-von-Guericke University Magdeburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Gene Expression Regulation, NeoplasticAntigens, CDAntigens, Differentiation, T-LymphocyteAntineoplastic AgentsATP-Binding Cassette, Sub-Family C ProteinsATP Binding Cassette Transporter, Subfamily BATP Binding Cassette Transporter, Subfamily G, Member 2CD4-Positive T-LymphocytesCD69 AntigensCD8-Positive T-LymphocytesCell ProliferationHumansJanus Kinase 2Lectins, C-TypeLymphocyte ActivationMutationABCB1 protein, humanABCG2 protein, humanAntigens, CDAntigens, Differentiation, T-LymphocyteAntineoplastic AgentsATP-Binding Cassette, Sub-Family C ProteinsATP Binding Cassette Transporter, Subfamily BATP Binding Cassette Transporter, Subfamily G, Member 2CD69 AntigensJak2 protein, mouseJanus Kinase 2Lectins, C-Typemultidrug resistance-associated protein 1Neoplasm ProteinsNitrilesphytohemagglutinin L protein, Phaseolus vulgarisPhytohemagglutininsProtein Kinase InhibitorsPyrazolesPyrimidinesruxolitinibABCB1ABCG2JAK2ruxolitinibT-cell

Identifiers

PMID26589910
PMCPMC4815733
OpenAlexW2244624159

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.