Evidence map›Paper›PMID 26589678›Full record

ArticleClinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology2016

Electroencephalography during general anaesthesia differs between term-born and premature-born children.

Ravi Poorun, Caroline Hartley, Sezgi Goksan, Alan Worley, Stewart Boyd, Laura Cornelissen, Charles Berde, Richard Rogers, Tariq Ali, Rebeccah Slater

Open access · hybridAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 24 citations in OpenAlex.

  1. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Ravi PoorunNuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK.
Caroline HartleyDepartment of Paediatrics, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK.
Sezgi GoksanNuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK.
Alan WorleyDepartment of Clinical Neurophysiology, Great Ormond Street Hospital for Children, London WC1N 3JH, UK.
Stewart BoydDepartment of Clinical Neurophysiology, Great Ormond Street Hospital for Children, London WC1N 3JH, UK.
Laura CornelissenDepartment of Anesthesiology, Perioperative and Pain Medicine, Boston Children's Hospital, Boston, MA 02115, USA.
Charles BerdeDepartment of Anesthesiology, Perioperative and Pain Medicine, Boston Children's Hospital, Boston, MA 02115, USA.
Richard RogersNuffield Department of Anaesthetics, John Radcliffe Hospital, Oxford OX3 9DU, UK.
Tariq AliNuffield Department of Anaesthetics, John Radcliffe Hospital, Oxford OX3 9DU, UK.
Rebeccah SlaterDepartment of Paediatrics, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK. Electronic address: rebeccah.slater@paediatrics.ox.ac.uk.
John Radcliffe Hospital · GBBoston Children's Hospital · USGreat Ormond Street Hospital · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesPremature birth is associated with a wide range of complications in later life, including structural and functional neurological abnormalities and altered pain sensitivity. We investigated whether during anaesthesia premature-born children display different patterns of background EEG activity and exhibit increased responses to nociceptive stimuli.

methodsWe examined background EEG and time-locked responses to clinical cannulation in 45 children (mean age (±SD) at study: 4.9(±3.0)years) under sevoflurane monoanaesthesia maintained at a steady-state end-tidal concentration of 2.5%. 15 were born prematurely (mean gestational age at birth: 29.2 ± 3.9 weeks) and 30 were age-matched term-born children.

resultsBackground levels of alpha and beta power were significantly lower in the premature-born children compared to term-born controls (p=0.048). Clinical cannulation evoked a significant increase in delta activity (p=0.032), which was not significantly different between the two groups (p=0.44).

conclusionsThe results indicate that whilst under anaesthesia premature-born children display different patterns of background brain activity compared to term-born children. SIGNIFICANCE: As electrophysiological techniques are increasingly used by anaesthetists to gauge anaesthetic depth, differences in background levels of electrophysiological brain activity between premature and term-born children may be relevant when considering titration of anaesthetic dose.

Indexed as

Anesthesia, GeneralChildChild, PreschoolElectroencephalographyFemaleHumansInfantInfant, NewbornInfant, PrematureMaleMethyl EthersPremature BirthSevofluraneTerm BirthMethyl EthersSevofluraneAnaesthesiaEEGNociceptionPreterm

Identifiers

PMID26589678
PMCPMC4725254
OpenAlexW2211351828

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.