ReviewJournal of diabetes science and technology2016
Artificial Pancreas Device Systems for the Closed-Loop Control of Type 1 Diabetes: What Systems Are in Development?
Review in Journal of diabetes science and technology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04509362 (An 8-Day Initiation Protocol of Advanced Hybrid Closed Loop System In Children and Adolescents With Diabetes Type 1 On Multiple Daily Insulin Injection), which is not on this map. Cited by 56 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
An 8-Day Initiation Protocol of Advanced Hybrid Closed Loop System In Children and Adolescents With Diabetes Type 1 On Multiple Daily Insulin Injection
Who cites it
56 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Capturing artificial intelligence applications' value proposition in healthcare - a qualitative research study.BMC health services research · 2024Pooled it
- Better TIR, HbA1c, and less hypoglycemia in closed-loop insulin system in patients with type 1 diabetes: a meta-analysis.BMJ open diabetes research & care · 2022Pooled it
- Analyzing the Potential of Advanced Insulin Dosing Strategies in Patients With Type 2 Diabetes: Results From a Hybrid In Silico Study.Journal of diabetes science and technology · 2018Trial
- A wearable closed-loop insulin micropump toward a miniaturized artificial pancreas for diabetes.Microsystems & nanoengineering · 2026Article
- Comparative Assessment of In Vivo and In Silico Evaluation of Automated Fluid Resuscitation Controllers.Annals of biomedical engineering · 2026Article
- Review
- Antidiabetic Close Loop Based on Wearable DNA-Hydrogel Glucometer and Implantable Optogenetic Cells.JACS Au · 2024Article
- Article
- Looking at the fringes of MedTech innovation: a mapping review of horizon scanning and foresight methods.BMJ open · 2023Review
- New therapies towards a better glycemic control in youths with type 1 diabetes.Pharmacological research · 2023Review
- Pediatric Type 1 Diabetes: Mechanisms and Impact of Technologies on Comorbidities and Life Expectancy.International journal of molecular sciences · 2023Review
- Investigating the value of glucodensity analysis of continuous glucose monitoring data in type 1 diabetes: an exploratory analysis.Frontiers in clinical diabetes and healthcare · 2023Article
- Effectiveness and safety of a model predictive control (MPC) algorithm for an artificial pancreas system in outpatients with type 1 diabetes (T1D): systematic review and meta-analysis.Diabetology & metabolic syndrome · 2022Review
- Adolescents' and their parents' experiences of using a closed-loop system to manage type 1 diabetes in everyday life: qualitative study.Chronic illness · 2022Article
- Design and analysis of crossover trials for investigating high-risk medical devices: A review.Contemporary clinical trials communications · 2022Review
- Review
- Evaluation of blood glucose level control in type 1 diabetic patients using deep reinforcement learning.PloS one · 2022Article
- Bioengineering the Vascularized Endocrine Pancreas: A Fine-Tuned Interplay Between Vascularization, Extracellular-Matrix-Based Scaffold Architecture, and Insulin-Producing Cells.Transplant international : official journal of the European Society for Organ Transplantation · 2022Review
- Closed-Loop Insulin Delivery Systems: Past, Present, and Future Directions.Frontiers in endocrinology · 2022 · on this mapReview
- Innovative features and functionalities of an artificial pancreas system: What do youth and parents want?Diabetic medicine : a journal of the British Diabetic Association · 2021Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundClosed-loop artificial pancreas device (APD) systems are externally worn medical devices that are being developed to enable people with type 1 diabetes to regulate their blood glucose levels in a more automated way. The innovative concept of this emerging technology is that hands-free, continuous, glycemic control can be achieved by using digital communication technology and advanced computer algorithms.
methodsA horizon scanning review of this field was conducted using online sources of intelligence to identify systems in development. The systems were classified into subtypes according to their level of automation, the hormonal and glycemic control approaches used, and their research setting.
resultsEighteen closed-loop APD systems were identified. All were being tested in clinical trials prior to potential commercialization. Six were being studied in the home setting, 5 in outpatient settings, and 7 in inpatient settings. It is estimated that 2 systems may become commercially available in the EU by the end of 2016, 1 during 2017, and 2 more in 2018.
conclusionsThere are around 18 closed-loop APD systems progressing through early stages of clinical development. Only a few of these are currently in phase 3 trials and in settings that replicate real life.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.