Evidence map›Paper›PMID 26589601›Full record

ArticleJournal of cardiovascular translational research2015

Genetic Factors Influencing B-type Natriuretic Peptide-Mediated Production of Cyclic Guanosine Monophosphate and Blood Pressure Effects in Heart Failure Patients.

David E Lanfear, Jia Li, Raza Abbas, Ricoung She, Badri Padhukasahasram, Ramesh C Gupta, David Langholz, W H Wilson Tang, L Keoki Williams, Hani N Sabbah and 1 more

Open access · greenAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cardiovascular translational research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Practical Pharmacogenomic Approaches to Heart Failure Therapeutics.Current treatment options in cardiovascular medicine · 2016
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

David E LanfearHeart and Vascular Institute, Henry Ford Hospital, Detroit, MI, USA. dlanfea1@hfhs.org.
Jia LiDepartment of Public Health Sciences, Henry Ford Hospital, Detroit, MI, USA.
Raza AbbasDepartment of Internal Medicine, Henry Ford Hospital, Detroit, MI, USA.
Ricoung SheDepartment of Public Health Sciences, Henry Ford Hospital, Detroit, MI, USA.
Badri PadhukasahasramCenter for Health Policy and Health Services Research, Henry Ford Hospital, Detroit, MI, USA.
Ramesh C GuptaHeart and Vascular Institute, Henry Ford Hospital, Detroit, MI, USA.
David LangholzSpectrum Health System, Grand Rapids, MI, USA.
W H Wilson TangHeart and Vascular Institute and Center for Clinical Genomics, Cleveland Clinic Foundation, Cleveland, OH, USA.
L Keoki WilliamsDepartment of Internal Medicine, Henry Ford Hospital, Detroit, MI, USA.
Hani N SabbahHeart and Vascular Institute, Henry Ford Hospital, Detroit, MI, USA.
Sheryl L ChowWestern University of Health Sciences, Pomona, CA, USA.
Henry Ford Hospital · USCleveland Clinic · USSpectrum Health · USWestern University of Health Sciences · US

Funding

Substrate Selection and Oxidative Stress in Heart FailureP01HL074237 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI SABBAH, HANI N · 2003 to 2013
$19.9M
PHARMACOGENOMICS OF INHALED CORTICOSTEROID RESPONSIVENESS IN PATIENTS WITH ASTHMAR01AI079139 · NIAID · HENRY FORD HEALTH SYSTEM · PI WILLIAMS, KEOKI · 2009 to 2013
$3.9M
Impact of Race and Genetic Factors on Beta-blocker Effectiveness in Heart FailureR01HL103871 · NHLBI · HENRY FORD HEALTH SYSTEM · PI LANFEAR, DAVID E · 2011 to 2015
$3.5M
Mechanism of Endotoxin's Effect On Allergy RiskR01AI061774 · NIAID · HENRY FORD HEALTH SYSTEM · PI WILLIAMS, KEOKI · 2004 to 2008
$2.9M
Combined Transcriptomics and Genomics to Find Asthma Genes in Admixed PopulationsR01HL118267 · NHLBI · HENRY FORD HEALTH SYSTEM · PI WILLIAMS, KEOKI · 2014 to 2017
$2.9M
VALIDATION OF ADHERENCE DATA--USE IN CLINICAL PRACTICER01DK064695 · NIDDK · HENRY FORD HEALTH SYSTEM · PI WILLIAMS, KEOKI · 2003 to 2010
$2.7M
USING INFORMATION TECHNOLOGY TO IMPROVE ASTHMA ADHERENCER01HL079055 · NHLBI · HENRY FORD HEALTH SYSTEM · PI WILLIAMS, KEOKI · 2005 to 2008
$1.4M
Pharmacogenetics of the B-type Natriuretic Peptide PathwayK23HL085124 · NHLBI · HENRY FORD HEALTH SYSTEM · PI LANFEAR, DAVID E · 2008 to 2012
$632k
NHLBI NIH HHS K23 HL085124NHLBI NIH HHS K23HL085124NHLBI NIH HHS L30 HL082148NHLBI NIH HHS P01 HL074237NHLBI NIH HHS P01HL074237NHLBI NIH HHS R01 HL079055NHLBI NIH HHS R01HL079055NHLBI NIH HHS R01 HL103871NHLBI NIH HHS R01HL103871NHLBI NIH HHS R01 HL118267NHLBI NIH HHS R01HL118267NIAID NIH HHS R01 AI061774NIAID NIH HHS R01AI061774NIAID NIH HHS R01 AI079139NIAID NIH HHS R01AI079139NIDDK NIH HHS R01 DK064695NIDDK NIH HHS R01DK064695
6 · The paper itself

Abstract

Natriuretic peptides (NPs) represent a critical pathway in heart failure (HF). We explored genetic determinants of pharmacodynamic effects of B-type NP (BNP) and changes in plasma cyclic guanosine monophosphate (cGMP) and blood pressure (BP). HF patients (n = 135) received recombinant human BNP (nesiritide) at standard doses, and plasma cGMP levels were measured at baseline and during infusion. We tested the association of 119 single nucleotide polymorphisms (SNPs) in 4 candidate genes (NPR1, NPR2, NPR3, and membrane metallo-endopeptidase (MME)) with the change in cGMP and BP. Gene-based testing for association of genetic variation with endpoints was significant only for MME. Upon individual SNP testing, two loci in MME were associated with ΔcGMP; another (rs16824656) showed association with BP change. In summary, the pharmacodynamic effects of BNP vary substantially in HF patients and are associated with genetic variation in MME. MME genetic variation may be an important determinant of NP-mediated effects in humans.

Indexed as

Genetic VariationAgedAged, 80 and overBlood PressureCohort StudiesFemaleGenotypeGuanosine MonophosphateHeart FailureHumansMaleMiddle AgedNatriuretic Peptide, BrainNeprilysinPharmacogeneticsSensitivity and SpecificityGuanosine MonophosphateNatriuretic Peptide, BrainNeprilysinDrug metabolismGenetic polymorphismsHeart failureNatriuretic peptidePharmacogenetics

Identifiers

PMID26589601
PMCPMC4686234
OpenAlexW2176292466

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.