ArticleBMC genomics2015
Gene expression profiling in non-human primate jejunum, ileum and colon after total-body irradiation: a comparative study of segment-specific molecular and cellular responses.
Article in BMC genomics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 26 citations in OpenAlex.
- Colonic epithelial regeneration shapes susceptibility tobioRxiv : the preprint server for biology · 2026Article
- Contribution of immune cells and cytokines to radiation-induced injury: the key roles and potential targets.Frontiers in immunology · 2026Review
- Routine CT Diagnostics Cause Dose-Dependent Gene Expression Changes in Peripheral Blood Cells.International journal of molecular sciences · 2025Article
- Characterization of a novel dual murine model of chemotherapy-induced oral and intestinal mucositis.Scientific reports · 2023Article
- Expression Profile of Housekeeping Genes and Tissue-Specific Genes in Multiple Tissues of Pigs.Animals : an open access journal from MDPI · 2022Article
- Lung transcriptome of nonhuman primates exposed to total- and partial-body irradiation.Molecular therapy. Nucleic acids · 2022Article
- Drivers of transcriptional variance in human intestinal epithelial organoids.Physiological genomics · 2021Article
- Polysaccharides extracted from Rheum tanguticum ameliorate radiation-induced enteritis via activation of Nrf2/HO-1.Journal of radiation research · 2021Article
- Biological Pathways Associated With the Development of Pulmonary Toxicities in Mesothelioma Patients Treated With Radical Hemithoracic Radiation Therapy: A Preliminary Study.Frontiers in oncology · 2021Article
- Plasticity of Paneth cells and their ability to regulate intestinal stem cells.Stem cell research & therapy · 2020Review
- Changes in miRNA expressions in the injured small intestine of mice following high‑dose radiation exposure.Molecular medicine reports · 2020Article
- NZO/HlLtJ as a novel model for the studies on the role of metabolic syndrome in acute radiation toxicity.International journal of radiation biology · 2020Article
- The Butyrogenic and Lactic Bacteria of the Gut Microbiota Determine the Outcome of Allogenic Hematopoietic Cell Transplant.Frontiers in microbiology · 2020Review
- Effects of Microcystin-LR on the Microstructure and Inflammation-Related Factors of Jejunum in Mice.Toxins · 2019Article
- Total body irradiation induced mouse small intestine senescence as a late effect.Journal of radiation research · 2019Article
- Gut microbial dysbiosis is associated with development and progression of radiation enteritis during pelvic radiotherapy.Journal of cellular and molecular medicine · 2019Article
- Mechanisms of Normal Tissue Injury From Irradiation.Seminars in radiation oncology · 2017Review
- Emerging Roles for Noncanonical NF-κB Signaling in the Modulation of Inflammatory Bowel Disease Pathobiology.Inflammatory bowel diseases · 2016Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
Abstract
backgroundAlthough extensive studies have investigated radiation-induced injuries in particular gastrointestinal (GI) segments, a systematic comparison among the different segments on the basis of mode, magnitude and mechanism has not been reported. Here, a comparative study of segment-specific molecular and cellular responses was performed on jejunum, ileum and colon obtained at three time points (4, 7 and 12 days after irradiation) from non-human primate (Rhesus macaque) models exposed to 6.7 Gy or 7.4 Gy total body irradiation (TBI).
resultsPathway analysis on the gene expression profiles identified radiation-induced time-, dose- and segment-dependent activation of tumor necrosis factor α (TNFα) cascade, tight junction, apoptosis, cell cycle control/DNA damage repair and coagulation system signaling. Activation of these signaling pathways suggests that colon sustained the severest mucosal barrier disruption and inflammation, and jejunum the greatest DNA damage, apoptosis and endothelial dysfunction. These more pronounced alterations correlate with the high incidence of macroscopic pathologies that are observed in the colon after TBI. Compared to colon and jejunum, ileum was resistant to radiation injury. In addition to the identification a marked increase of TNFα cascade, this study also identified radiation induced strikingly up-regulated tight junction gene CLDN2 (196-fold after 7.4-Gy TBI), matrix degradation genes such as MMP7 (increased 11- and 41-fold after 6.7-Gy and 7.4-Gy TBI), and anoikis mediated gene EDA2R that mediate mucosal shedding and barrier disruption.
conclusionsThis is the first systematic comparative study of the molecular and cellular responses to radiation injury in jejunum, ileum and colon. The strongest activation of TNFα cascades and the striking up-regulation of its down-stream matrix-dissociated genes suggest that TNFα modulation could be a target for mitigating radiation-induced mucosal barrier disruption.
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