ArticleInternational archives of occupational and environmental health2016
Using exposure windows to explore an elusive biomarker: blood manganese.
Article in International archives of occupational and environmental health, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 26 citations in OpenAlex.
- Altered manganese and iron biomarkers in welders: a multi-element biomonitoring study across blood, serum and urine.Frontiers in public health · 2026Article
- Follow-up Biomonitoring Study of Metal Exposure in Apprentice Welders in Montreal, Quebec, During Gas Metal Arc Welding (GMAW).Biological trace element research · 2025Article
- Neuroprotective Effect of Vitamin D on Behavioral and Oxidative Parameters of Male and Female Adult Wistar Rats Exposed to Mancozeb (manganese/zinc ethylene bis-dithiocarbamate).Molecular neurobiology · 2023Article
- Fine Particulate Matter and Lung Function among Burning-ExposedEnvironmental health perspectives · 2022Article
- Short Report: Using Targeted Urine Metabolomics to Distinguish Between Manganese Exposed and Unexposed Workers in a Small Occupational Cohort.Frontiers in public health · 2021Article
- The reproducibility of urinary ions in manganese exposed workers.Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) · 2019Article
- Association of heavy metals with measures of pulmonary function in children and youth: Results from the National Health and Nutrition Examination Survey (NHANES).Environment international · 2018Article
- Toenail Manganese: A Sensitive and Specific Biomarker of Exposure to Manganese in Career Welders.Annals of work exposures and health · 2017Article
- The Use of Metabolomics to Identify Biological Signatures of Manganese Exposure.Annals of work exposures and health · 2017Article
- Longitudinal T1 relaxation rate (R1) captures changes in short-term Mn exposure in welders.Neurotoxicology · 2016Article
- Diagnosis of manganism and manganese neurotoxicity: A workshop report.Medicine internationalArticle
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
purposeWe sought to understand the time course between exposure to manganese (Mn) and uptake into the blood, to allow a more meaningful interpretation of exposure biomarker data, and to determine the utility of blood as a biomarker of Mn exposure.
methodsWelder trainees were monitored over the course of a five-quarter training program. Each quarter, trainees gave eight blood samples and had personal air monitoring four times. A mixed model was fit to obtain estimates of airborne exposure by welding type (fixed effect), adjusted for subject (random effect). Considering weekends and days absent as zero exposure, estimated exposures were summed over various exposure windows and related to measured blood manganese (MnB) using a mixed model.
resultsA relationship consistent with zero was found between MnB and modeled 1 or 7 days of exposure. After 30 days of preceding exposure, a 1 mg-days/m(3) increase in air Mn is associated with a 0.57 ng/mL increase in MnB (95% CI -0.04, 1.19). Considering a 90-day exposure window and a cumulative exposure window, a 1 mg-days/m(3) increase in air Mn is associated with a 0.26 (95% CI 0.005, 0.51) and 0.09 (95% CI 0.006, 0.17) ng/mL increase in MnB, respectively.
conclusionsFrom this analysis, MnB may begin to act as a biomarker of Mn exposure over longer time periods, or at higher levels of exposure. This novel study design allowed investigation of how MnB relates to different time windows of exposure, representing the most robust Mn exposure assessment in the biomarker literature.
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